The study of dry biological valve crosslinked with a combination of carbodiimide and polyphenol

The glutaraldehyde crosslinked pericardium has been used in bioprosthetic valves for about 50 years. However, problems such as glutaraldehyde residue and calcification still exist in current commercial products. Non-glutaraldehyde crosslinked dry valve is an important strategy to solve those problems. In this study, a non-glutaraldehyde crosslinked dry biological valve material was obtained by the combined crosslinking of carbodiimide (EDC) and...