Yunbing Wang
Sichuan University
ProdrugMicelleBiophysicsDrug carrierBiomedical engineeringCopolymerNanotechnologyNanocarriersChemistryMaterials scienceIn vivoPhosphorylcholineBiocompatibilityGlutaraldehydeChitosanDrug deliveryCalcificationCoatingChemical engineeringAdhesion
221Publications
15H-index
1,394Citations
Publications 131
Newest
#1Tao Yu (Sichuan University)H-Index: 5
#2Xiaotong Chen (Sichuan University)
Last. Yunbing Wang (Sichuan University)H-Index: 15
view all 9 authors...
Abstract Heart valve diseases, such as valve stenosis and regurgitation, are one of the important reasons for the high morbidity and mortality of cardiovascular diseases, and the heart valve replacement has become the optimal option for severe heart valve disease treatment. With the development of transcatheter heart valve replacement technology and aging population, the usage of bioprosthetic heart valves (BHVs) has been largely expanded. As the golden standard reagent, glutaraldehyde (Glut) ha...
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#1Mi Hu (ZJU: Zhejiang University)H-Index: 9
#2Fan Jia (ZJU: Zhejiang University)H-Index: 10
Last. Jian Ji (ZJU: Zhejiang University)H-Index: 56
view all 10 authors...
2 CitationsSource
#1Cheng Hu (Sichuan University)H-Index: 8
#2Linyu Long (Sichuan University)H-Index: 1
Last. Yunbing Wang (Sichuan University)H-Index: 15
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Abstract The healing of chronic diabetic wounds remains a key challenge due to its susceptibility to bacterial infection, the inflammatory wound microenvironment, and difficulty in angiogenesis. Herein, a pH-responsive, mussel-inspired, double-crosslinking injectable, and adhesive smart hydrogel formula was exploited to overcome these obstacles simultaneously. The multifunctional double-crosslinking hydrogel was developed through the formation of catechol−catechol adducts and a Schiff-based reac...
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#1Fan Yang (Sichuan University)H-Index: 1
#2Haiyang He (Sichuan University)H-Index: 3
Last. Yunbing Wang (Sichuan University)H-Index: 15
view all 6 authors...
Bioprosthetic heart valve (BHV) replacement is increasingly used for treating valve-related diseases worldwide but the current commercially used BHVs treated with glutaraldehyde (Glut) often failed within 12-15 years due to degradation, thrombosis, inferior biocompatibility and calcification. Herein, 3-glycidyloxypropyl trimethoxysilane (GPTMS) was used to crosslink porcine pericardium (PP) at the concentration (v/v) of 0.25%, 1%, 2%, and 4% and their performance for potential application in BHV...
1 CitationsSource
#1Fan Yang (Sichuan University)H-Index: 1
#2Liangpeng Xu (Sichuan University)H-Index: 1
Last. Yunbing Wang (Sichuan University)H-Index: 15
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Abstract Although transcatheter aortic valve implantation (TAVI) has been proven with excellent effectiveness and safety, the subclinical leaflet thrombosis (SLT) and structural valve deterioration (SVD) are two main factors threatening the service lifespan of the transcatheter aortic valve (TAV) because the glutaraldehyde (Glut) crosslinked tissue as leaflet material for the current clinically used TAV has high calcification propensity and thrombogenicity. In this study, zwitterionic monomer su...
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Use of a drug-eluting coated balloon (DCB) represents a promising therapeutic method for peripheral arterial disease (PAD) due to its advantages such as no implant permanently retained in the patient and no inflammatory reaction and endothelialization barrier caused by a permanent stent. However, there is still a huge challenge of controlling the release of drugs from the DCB into vessel tissue. The uncontrolled release of drugs and high drug loading amounts could potentially lead to distal embo...
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#1Fanjun ZhangH-Index: 5
#2Cheng HuH-Index: 8
Last. Yunbing WangH-Index: 15
view all 9 authors...
Hospital-acquired infections and thrombosis caused by bacteria attached to the device surface, or fibrin crosslinking owing to platelet accumulation/activation, are major healthcare challenges that cause morbidity and mortality. To prevent these, surface coating technologies are considered an efficient tool that can combine hemocompatibility and bactericidal activity. In this study, surface-initiated polymerization was conducted to form all-in-one hydrogel coating that could adapt to diverse med...
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#1Li Yang (Sichuan University)H-Index: 29
#2Shuang Xie (Sichuan University)
Last. Yunbing Wang (Sichuan University)H-Index: 15
view all 5 authors...
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#1Xiaorong Lan (Sichuan University)H-Index: 5
Last. Yunbing WangH-Index: 15
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#1Binggang Wu (Sichuan University)
#2Cheng Zheng (Sichuan University)
Last. Yunbing Wang (Sichuan University)H-Index: 15
view all 9 authors...
Heart valve replacement is an effective therapy for patients with moderate to severe valvular stenosis or regurgitation. Most bioprosthetic heart valves applied clinically are based on cross-linking with glutaraldehyde (GLUT), but they have some drawbacks like high cytotoxicity, severe calcification, and poor hemocompatibility. In this study, we focused on enhancing the properties of bioprosthetic heart valves by cross-linking with 3,4-dihydroxybenzaldehyde (DHBA). The experiment results reveale...
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