Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study

Published on Nov 13, 2020in Environmental Science & Technology9.028
· DOI :10.1021/ACS.EST.0C05972
Christopher D. Kassotis17
Estimated H-index: 17
(Duke University),
Nicholas J Herkert7
Estimated H-index: 7
(Duke University)
+ 5 AuthorsHeather M. Stapleton82
Estimated H-index: 82
(Duke University)
Sources
Abstract
Research suggests that thyroid cancer incidence rates are increasing, and environmental exposures have been postulated to be playing a role. To explore this possibility, we conducted a pilot study to investigate the thyroid disrupting bioactivity of chemical mixtures isolated from personal silicone wristband samplers within a thyroid cancer cohort. Specifically, we evaluated TRβ antagonism of chemical mixtures extracted from wristbands (n = 72) worn by adults in central North Carolina participating in a case-control study on papillary thyroid cancer. Sections of wristbands were solvent-extracted and analyzed via mass spectrometry to quantify a suite of semivolatile chemicals. A second extract from each wristband was used in a bioassay to quantify TRβ antagonism in human embryonic kidney cells (HEK293/17) at concentrations ranging from 0.1 to 10% of the original extract (by volume). Approximately 70% of the sample extracts tested at a 1% extract concentration exhibited significant TRβ antagonism, with a mean of 30% and a range of 0-100%. Inhibited cell viability was noted in >20% of samples that were tested at 5 and 10% concentrations. Antagonism was positively associated with wristband concentrations of several phthalates, organophosphate esters, and brominated flame retardants. These results suggest that personal passive samplers may be useful in evaluating the bioactivities of mixtures that people contact on a daily basis. We also report tentative associations between thyroid receptor antagonism, chemical concentrations, and papillary thyroid cancer case status. Future research utilizing larger sample sizes, prospective data collection, and measurement of serum thyroid hormone levels (which were not possible in this study) should be utilized to more comprehensively evaluate these associations.
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#1Tomoko Fujitani (Kyoto University)H-Index: 2
#2Sani Rachman Soleman (Kyoto University)H-Index: 3
Last. Hatasu Kobayashi (Mie University)H-Index: 1
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#1Zhi Tang (HUST: Huazhong University of Science and Technology)H-Index: 13
#2Jianqing Zhang (CDC: Centers for Disease Control and Prevention)H-Index: 17
Last. Guibin Jiang (CAS: Chinese Academy of Sciences)H-Index: 102
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#1Catherine F. Wise (NCSU: North Carolina State University)H-Index: 5
#2Stephanie C. Hammel (Duke University)H-Index: 14
Last. Matthew BreenH-Index: 57
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Silicone wristbands are promising passive samplers to support epidemiology studies in characterizing exposure to organic contaminants; however, investigating associated health risks remains challen...
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#1Vincenzo MarottaH-Index: 19
#2Pasqualino Malandrino (University of Catania)H-Index: 19
Last. Luciano PezzulloH-Index: 19
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Abstract Incidence and mortality of thyroid cancer are increasing, thus making mandatory to improve the knowledge of disease etiology. The hypothesis of a role for anthropogenic chemicals is raising wide consideration. A series of occupational studies revealed that job exposures with high risk of chemical contamination were usually more prone to thyroid cancer development. These include shoe manufacture, preserving industry, building activities, pulp/papermaker industry and the wood processing, ...
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#1Zhi Tang (HUST: Huazhong University of Science and Technology)H-Index: 13
#2Jianqing Zhang (CDC: Centers for Disease Control and Prevention)H-Index: 17
Last. Guibin Jiang (CAS: Chinese Academy of Sciences)H-Index: 102
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#1Stephanie C. Hammel (Duke University)H-Index: 14
#2Kate Hoffman (Duke University)H-Index: 32
Last. Heather M. Stapleton (Duke University)H-Index: 82
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Organophosphate esters (OPEs) are applied as additive flame retardants, and along with phthalates, are also used as plasticizers in consumer products. As such, human exposure is common and chronic....
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#1Aalekhya Reddam (UCR: University of California, Riverside)H-Index: 6
#2George Tait (Duke University)H-Index: 1
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Abstract Organophosphate esters (OPEs) are a class of semi-volatile organic compounds (SVOCs) used as flame retardants, plasticizers, and anti-foaming agents. Due to stringent flammability standards in vehicles and the ability of OPEs to migrate out of end-use products, elevated concentrations of OPEs have been found in car dust samples around the world. As many residents of Southern California spend a significant amount of time in their vehicles, there is potential for increased exposure to OPE...
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#1Chong Liu (HUST: Huazhong University of Science and Technology)H-Index: 12
#2Yan-Ling Deng (HUST: Huazhong University of Science and Technology)H-Index: 7
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Abstract Phthalates have been reported to affect the function and growth of thyroid. However, there is little data on the effect of phthalates on thyroid oncogenesis. Here we explored the associations between phthalates exposure and the risks of thyroid cancer and benign nodule. We sex-matched 144 thyroid cancer, 138 benign nodule patients and 144 healthy adults from Wuhan, China. Eight phthalate metabolites in spot urine samples were quantified using high-performance liquid chromatography and t...
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#1Hongjian Miao (CFS: Center for Food Safety)H-Index: 4
#2Xin Liu (Wuhan Polytechnic University)H-Index: 16
Last. Yongning Wu (CFS: Center for Food Safety)H-Index: 72
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Abstract Some studies have revealed thyrotoxicity of phthalates; however, associations of phthalate exposure with papillary thyroid cancer (PTC) remain unclear. We conducted a pair-matching case-control study of 111 PTC cases and 111 age- and sex-matched non-PTC controls to examine associations between urinary concentrations of phthalate metabolites and PTC. Phthalate metabolites were determined in fasting urine specimens by ultra-performance liquid chromatography – tandem mass spectrometry (UPL...
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#1Shaorui Wang (IU: Indiana University)H-Index: 14
#2Kevin RomanakH-Index: 14
Last. Marta VenierH-Index: 32
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Abstract Silicone wristbands are being increasingly used to assess human exposure to semi-volatile organic compounds (SVOCs). However, it is unclear what exposure pathways wristbands integrate. To test the hypothesis that wristbands integrate inhalation and dermal exposures, we measured 38 chemicals from four compound groups (PAHs, PBDEs, nBFRs, and OPEs) in silicone wristbands and brooches, active air samples (Occupational Safety and Health Administration Versatile Sampler or OVS cartridge), an...
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Background null Exposure assessment is critical for connecting environmental pollutants to health outcomes and evaluating impacts of interventions or environmental policies. Silicone wristbands (SWBs) show promise for multi-pollutant exposure assessment, including polycyclic aromatic hydrocarbons (PAHs), a ubiquitous class of toxic environmental pollutants. null Objective null To review published studies where SWBs were worn on the wrist for human environmental exposure assessments and evaluate ...
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