Christopher D. Kassotis
Duke University
Environmental chemistryContaminationOffspringAdipogenesisInternal medicineEndocrinologyChemistryUnconventional oilEstrogenAntagonismTriglycerideHydraulic fracturingObesogenEnvironmental scienceEndocrine systemThyroidWaste managementNatural gasHormoneMedicineGroundwaterSurface waterBiologyWastewater
39Publications
16H-index
970Citations
Publications 39
Newest
#1Christopher D. Kassotis (Duke University)H-Index: 16
#2Kate Hoffman (Duke University)H-Index: 29
Last. Astrid Saraceni (UNITO: University of Turin)
view all 0 authors...
The 3T3-L1 murine pre-adipocyte line is an established cell culture model for screening Metabolism Disrupting Chemicals (MDCs). Despite a need to accurately identify MDCs for further evaluation, relatively little research has been performed to comprehensively evaluate reproducibility across laboratories, assess factors that might contribute to varying degrees of differentiation between laboratories (media additives, plastics, cell source, etc.), or to standardize protocols. As such, the goals of...
Source
#1Christopher D. Kassotis (Duke University)H-Index: 16
#2Kate Hoffman (Duke University)H-Index: 29
Last. Heather M. Stapleton (Duke University)H-Index: 79
view all 7 authors...
Abstract In this study, we sought to expand our previous research on associations between bioactivities in dust and associated organic contaminants. Dust samples were collected from central NC homes (n = 188), solvent extracted, and split into two fractions, one for analysis using three different bioassays (nuclear receptor activation/inhibition and adipocyte development) and one for mass spectrometry (targeted measurement of 124 organic contaminants, including flame retardants, polychlorinated ...
Source
#1Christopher D. Kassotis (Duke University)H-Index: 16
#2Nicholas J Herkert (Duke University)H-Index: 7
Last. Heather M. Stapleton (Duke University)H-Index: 79
view all 8 authors...
Research suggests that thyroid cancer incidence rates are increasing, and environmental exposures have been postulated to be playing a role. To explore this possibility, we conducted a pilot study to investigate the thyroid disrupting bioactivity of chemical mixtures isolated from personal silicone wristband samplers within a thyroid cancer cohort. Specifically, we evaluated TRβ antagonism of chemical mixtures extracted from wristbands (n = 72) worn by adults in central North Carolina participat...
Source
#1Christopher D. Kassotis (Duke University)H-Index: 16
#2Jennifer S. Harkness (USGS: United States Geological Survey)H-Index: 10
Last. Susan C. Nagel (MU: University of Missouri)H-Index: 30
view all 13 authors...
The rise of hydraulic fracturing and unconventional oil and gas (UOG) exploration in the United States has increased public concerns for water contamination induced from hydraulic fracturing fluids and associated wastewater spills. Herein, we collected surface and groundwater samples across Garfield County, Colorado, a drilling-dense region, and measured endocrine bioactivities, geochemical tracers of UOG wastewater, UOG-related organic contaminants in surface water, and evaluated UOG drilling p...
Source
#1Christopher D. Kassotis (Duke University)H-Index: 16
#2Laura N. Vandenberg (UMass: University of Massachusetts Amherst)H-Index: 47
Last. Leonardo Trasande (NYU: New York University)H-Index: 53
view all 6 authors...
Summary Endocrine-disrupting chemicals (EDCs) substantially cost society as a result of increases in disease and disability but—unlike other toxicant classes such as carcinogens—have yet to be codified into regulations as a hazard category. This Series paper examines economic, regulatory, and policy approaches to limit human EDC exposures and describes potential improvements. In the EU, general principles for EDCs call for minimisation of human exposure, identification as substances of very high...
Source
#1Susan C. Nagel (MU: University of Missouri)H-Index: 30
#2Christopher D. Kassotis (Duke University)H-Index: 16
Last. V.D. Balise (UNM: University of New Mexico)H-Index: 1
view all 6 authors...
Abstract Unconventional oil and natural gas extraction (UOG) combines directional drilling and hydraulic fracturing and produces billions of liters of wastewater per year. Herein, we review experimental studies that evaluated the potential endocrine-mediated health impacts of exposure to a mixture of 23 UOG chemicals commonly found in wastewater. The purpose of this manuscript is to synthesize and summarize a body of work using the same UOG-mix but with different model systems and physiological ...
Source
#1Jane MunckeH-Index: 11
#2Anna-Maria Andersson (UCPH: University of Copenhagen)H-Index: 82
Last. Martin Scheringer (Masaryk University)H-Index: 73
view all 33 authors...
Food packaging is of high societal value because it conserves and protects food, makes food transportable and conveys information to consumers. It is also relevant for marketing, which is of economic significance. Other types of food contact articles, such as storage containers, processing equipment and filling lines, are also important for food production and food supply. Food contact articles are made up of one or multiple different food contact materials and consist of food contact chemicals....
Source
Unconventional oil and gas (UOG) extraction (fracking) has increased in the United States, as well as interest in the associated risks and benefits. This study’s purpose was to qualitatively examin...
Source
#1Victoria D. Balise (MU: University of Missouri)H-Index: 5
#2Jennifer N. Cornelius-Green (MU: University of Missouri)H-Index: 4
Last. Susan C. Nagel (MU: University of Missouri)H-Index: 30
view all 12 authors...
Chemicals used in unconventional oil and gas (UOG) operations can act as endocrine disrupting chemicals and metabolic disruptors. Our lab has reported altered energy expenditure and activity in C57BL/6J mice that were periconceptionally, gestationally, and lactationally exposed via maternal drinking water to a laboratory-created mixture of 23 UOG chemicals from gestational day 1 to postnatal day 21 in seven-month-old female mice with no change in body composition. We hypothesized that allowing t...
Source
#1Victoria D. Balise (MU: University of Missouri)H-Index: 5
#2Jennifer N. Cornelius-Green (MU: University of Missouri)H-Index: 4
Last. Susan C. Nagel (MU: University of Missouri)H-Index: 30
view all 6 authors...
Previous studies conducted in our laboratory have found altered adult health outcomes in animals with prenatal exposure to environmentally relevant levels of unconventional oil and gas (UOG) chemicals with endocrine-disrupting activity. This study aimed to examine potential metabolic health outcomes following a preconception, prenatal and postnatal exposure to a mixture of 23 UOG chemicals. Prior to mating and from gestation day 1 to postnatal day 21, C57BL/6J mice were developmentally exposed t...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.