Obesity and muscle may have synergic effect more than independent effects on brain volume in community-based elderly

To evaluate the individual and combined effects of obesity and muscle mass on brain volume in a community-dwelling healthy older population. One thousand two hundred nine participants (M:F = 574:635, mean age 63.6 ± 6.9 years) were included. The cross-sectional area of visceral fat (VF), the height-adjusted appendicular skeletal muscle mass (ASM/height2), and the ratio of thigh muscle to visceral fat (TM/VF) represented obesity, muscle mass, and...