A Medical Research and Evaluation Facility (MREF) and Studies Supporting the Medical Chemical Defense Program on Task 89-03: Test Up to 20 Candidate Topical Protectants

: Fourteen candidate topical skin protectants (TSPs) were examined in a multiple-phase testing regimen that included a variety of testing models designed to assess different aspects of TSP efficacy. Phase I initial efficacy tests were performed using both in vitro and in vivo models. The Phase I in vitro model involved determining the penetration profile of a challenge dose of chemical surety materiel (CSM), either soman (GD), VX, or thickened...