David W. Hobson
University of Texas at San Antonio
PathophysiologySurgeryPathologyDermatologyOrganelleApoptosisIn vitroIn vivoBasement membraneInflammationHuman skinDermisStratum corneumWeanlingAntigenicityStratum granulosumSomanSulfur mustardEpidermisCooperative Human Tissue NetworkToxicityEnd pointIn vitro analysisIn vivo analysisDermal irritationErythrocyte acetylcholinesteraseAlternative methodsIn vitro modelTreatment regimenNew zealand whiteNecrosisHistopathologyMedicineBiologyPharmacology
5Publications
2H-index
86Citations
Publications 5
Newest
#1David W. HobsonH-Index: 2
#2James A. BlankH-Index: 6
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#1Carl T. OlsonH-Index: 3
#2Thomas H. SniderH-Index: 7
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Abstract : Two human skin culture models, also known as human skin equivalents (HSEs), and dermatomed (split thickness) natural human skin (NHS) were assessed for use in studies investigating the dermatotoxic effects of sulfur mustard BIS(2-CHLOROETHYL) SULFIDE; HD. The HSEs examined were model ZK1300 from Advanced Tissue Sciences (ATS, La Jolla, CA) and Epiderm from MatTek Corporation (Ashland, MA). NHS specimens were obtained either fresh from the Ohio State University branch of the Cooperativ...
#1Nancy A. Monteiro-Riviere (NCSU: North Carolina State University)H-Index: 74
#2Alfred O. Inman (NCSU: North Carolina State University)H-Index: 21
Last. David W. Hobson (UTSA: University of Texas at San Antonio)H-Index: 2
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EpiDermy, an in vitro human skin equivalent (HSE), was compared to normal human breast skin (NHS) to morphologically and biochemically assess its feasibility for dermatologi- cal research. Intralot and interlot variability was studied in day 0, 1, 2, and 3 in vitro cultures and in day 0, 3, 5, and 7 NHS. For NHS, light microscopy (LM) at day 0 showed stratified epidermis which exhibited an increase in vacuoles and dark basal cells as storage increased to 3, 5, and 7 days. Transmission electron m...
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Sulfur mustard (2,2' dichlorodiethyl sulfide, HD) is a chemical warfare agent that is easily produced, and may be used against civilian populations as well as against military troops. However, good therapeutic and prophylactic measures await a better understanding of the pathophysiology of lesions produced by this agent. Because the skin remains is one of the principal routes for HD exposure and damage, the study of HD-induced skin lesions is of major interest. Blister formation is a characteris...
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#1David W. HobsonH-Index: 2
#2Thomas H. SniderH-Index: 7
Abstract : Fourteen candidate topical skin protectants (TSPs) were examined in a multiple-phase testing regimen that included a variety of testing models designed to assess different aspects of TSP efficacy. Phase I initial efficacy tests were performed using both in vitro and in vivo models. The Phase I in vitro model involved determining the penetration profile of a challenge dose of chemical surety materiel (CSM), either soman (GD), VX, or thickened soman (TGD), through a 0.1 mm thick film of...
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