Hepatic pyruvate carboxylase expression differed prior to hyperketonemia onset in transition dairy cows

Fatty acids ( FA ) provide an energy source to the liver during negative energy balance; however, when FA influx is excessive, FA can be stored as liver lipids or incompletely oxidized to β-hydroxybutyrate ( BHB ). The objectives of this study were to quantify plasma and liver FA profiles and hepatic gene expression in cows diagnosed with hyperketonemia ( HYK ; BHB ≥ 1.2 m M ) or not ( nonHYK ; BHB < 1.2 m M ) to determine a relationship...