Nutrient‐induced hyperosmosis evokes vasorelaxation via TRPV1 channel‐mediated, endothelium‐dependent, hyperpolarisation in healthy and colitis mice

Background and Purpose In humans, blood flow in the mesenteric circulation is greatly increased after meals, but the mechanisms underlying postprandial mesenteric vasorelaxation induced by nutrients and whether this process is involved in the pathogenesis of colitis, are not well understood. Here we have studied the direct actions of nutrients on mesenteric arterial tone and the underlying molecular mechanisms in healthy and colitis mice....