Endothelin‐1 potentiates TRPV1‐mediated vasoconstriction of human adipose arterioles in a protein kinase C‐dependent manner

The TRPV cation channels have emerged as important regulators of vascular tone. TRPV1 channels and endothelin-1 are independently associated with the pathophysiology of coronary vasospasm, but the relationship between their vasomotor functions remains unclear. We characterized the vasomotor function of TRPV1 channels in human arterioles and investigated regulation of their vasomotor function by endothelin-1.Human arterioles (mainly from adipose...