Intestinal absorption and hepatic elimination of drugs in high‐fat high‐cholesterol diet‐induced non‐alcoholic steatohepatitis rats: exemplified by simvastatin

Background and Purpose Altered drug pharmacokinetics is a significant concern in non‐alcoholic steatohepatitis (NASH) patients. Although high‐fat high‐cholesterol (HFHC) diet‐induced NASH (HFHC‐NASH) rats could simulate the typical dysregulation of cholesterol in NASH patients, experimental investigation on the altered drug pharmacokinetics in this model are limited. Thus, the present study comprehensive investigates the nature of such altered...