Original paper
Global brain volume and N-acetyl-aspartate decline over seven decades of normal aging
Abstract
We characterize the whole-brain N-acetyl-aspartate (WBNAA) and brain tissue fractions across the adult lifespan and test the hypothesis that, despite age-related atrophy, neuronal integrity (reflected by WBNAA) is preserved in normal aging. Two-hundred-and-seven participants: 133 cognitively intact older adults (73.6 ± 7.4 mean ± standard deviation, range: 60–90 year old) and 84 young (37.9 ± 11, range: 21–59 year old) were scanned with proton...
Paper Details
Title
Global brain volume and N-acetyl-aspartate decline over seven decades of normal aging
Published Date
Feb 1, 2021
Journal
Volume
98
Pages
42 - 51
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Notes
History