Adintoviruses: A Proposed Animal-Tropic Family of Midsize Eukaryotic Linear dsDNA (MELD) Viruses

Published on Oct 1, 2020in Virus Evolution5.549
· DOI :10.1093/VE/VEAA055
Gabriel J. Starrett21
Estimated H-index: 21
,
Michael J. Tisza7
Estimated H-index: 7
+ 4 AuthorsChristopher B. Buck52
Estimated H-index: 52
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#1Ian N. Boys (UTSW: University of Texas Southwestern Medical Center)H-Index: 4
#2Katrina B. Mar (UTSW: University of Texas Southwestern Medical Center)H-Index: 9
Last. John W. Schoggins (UTSW: University of Texas Southwestern Medical Center)H-Index: 31
view all 3 authors...
The Receptor Transporter Protein (RTP) family is present in most, if not all jawed vertebrates. Most of our knowledge of this protein family comes from studies on mammalian RTPs, which are multi-function proteins that regulate cell-surface G-protein coupled receptor levels, influence olfactory system development, regulate immune signaling, and directly inhibit viral infection. However, mammals comprise less than one-tenth of extant vertebrate species, and our knowledge about the expression, func...
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#1Thomas Hackl (MPG: Max Planck Society)H-Index: 10
#2Sarah Duponchel (MPG: Max Planck Society)H-Index: 2
Last. Matthias G. Fischer (MPG: Max Planck Society)H-Index: 15
view all 5 authors...
Endogenous viral elements (EVEs) are frequently found in eukaryotic genomes, yet their integration dynamics and biological functions remain largely unknown. Unlike most other eukaryotic DNA viruses, the virophage mavirus integrates efficiently into the nuclear genome of its host, the marine heterotrophic flagellate Cafeteria burkhardae. Mavirus EVEs can reactivate upon superinfection with the lytic giant virus CroV and may act as an adaptive antiviral defense system, because mavirus increases ho...
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