CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson’s disease

There is no consensus on the exact role of the adaptive immune system in Parkinson’s disease pathogenesis, although there is increasing evidence that it is somehow involved. Moreover, T cell infiltration in the brain has not been thoroughly studied in Parkinson’s disease and no study has assessed the infiltration in incidental Lewy body diseases cases that are considered to be early presymptomatic stages of the disease. In this study, we...