Gene

microRNA

Extracellular vesicle

Food and drug administration

Cell biology

Extracellular vesicles

Biology

Mesenchymal stem cell

Microvesicles

Surgery

Hemostasis

Stem cell

Extracellular

Vesicle

Biochemistry

Computational biology

Immunology

Drug delivery

Organic chemistry

Membrane

Internal medicine

Pharmacology

Regenerative medicine

Medicine

Chemistry

Platelet

Trends in biotechnology

There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for regenerative medicine and drug delivery. Blood-borne platelets represent a source of therapeutic EVs that is so far largely unexplored. Advantages of platelets as a cellular source of EVs include their established clinical value, regulated collection procedures, availability in a concentrated form, propensity to generate EVs, and unique composition and tissue-targeting capacity. This review analyzes the unique potential of platelet-derived (p-) EVs as therapeutic modalities and presents their inherent translational advantages for hemostasis, for regenerative medicine, and as drug-delivery vehicles.

Prospective Therapeutic Applications of Platelet Extracellular Vesicles