Trends in Biotechnology
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#1Xiongjie Zheng (KAUST: King Abdullah University of Science and Technology)H-Index: 7
#2Hendrik N.J. Kuijer (KAUST: King Abdullah University of Science and Technology)
Last. Salim Al-Babili (KAUST: King Abdullah University of Science and Technology)H-Index: 50
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Carotenoids are micronutrients important for human health. The continuous improvements in clustered regularly interspaced short palindromic repeats (CRISPR)-based genome-editing techniques make rapid, DNA/transgene-free and targeted multiplex genetic modification a reality, thus promising to accelerate the breeding and generation of ‘golden’ staple crops. We discuss here the progress and future prospects of CRISPR/Cas9 applications for carotenoid biofortification.
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#1Margrethe A. Boyd (NU: Northwestern University)H-Index: 4
#2Neha P. Kamat (NU: Northwestern University)H-Index: 15
The combination of biological and synthetic materials has great potential to generate new types of biosensors. Toward this goal, recent advances in artificial cell development have demonstrated the capacity to detect a variety of analytes and environmental changes by encapsulating genetically encoded sensors within bilayer membranes, expanding the contexts within which biologically based sensing can operate. This chassis not only acts as a container for cell-free sensors, but can also play an ac...
1 CitationsSource
#1Yonghao Cui (NUS: National University of Singapore)H-Index: 2
#2Kun-Lin Yang (NUS: National University of Singapore)H-Index: 33
Last. Kang Zhou (NUS: National University of Singapore)H-Index: 14
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Clostridium fermentations have been developed for producing butanol and other value-added chemicals, but their development is constrained by some limitations, such as relatively high substrate cost and the need to maintain an anaerobic condition. Recently, co-culture is emerging as a popular way to address these limitations by introducing a partner strain with Clostridium. Generally speaking, the co-culture strategy enables the use of a cheaper substrate, maintains the growth of Clostridium with...
2 CitationsSource
#1Cathrin Gräwe (Radboud University Nijmegen)H-Index: 3
#2Suzan Stelloo (Radboud University Nijmegen)H-Index: 3
Last. Michiel Vermeulen (Radboud University Nijmegen)H-Index: 56
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RNA-protein interactions play an important role in numerous cellular processes in health and disease. In recent years, the global RNA-bound proteome has been extensively studied, uncovering many previously unknown RNA-binding proteins. However, little is known about which particular proteins bind to which specific RNA transcript. In this review, we provide an overview of methods to identify RNA-protein interactions, with a particular focus on strategies that provide insights into the interactome...
3 CitationsSource
#1Francisco Javier Molina-Hidalgo (UGent: Ghent University)H-Index: 6
#2Marta Vazquez-Vilar (CSIC: Spanish National Research Council)H-Index: 9
Last. Alain Goossens (UGent: Ghent University)H-Index: 63
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Molecular farming intends to use crop plants as biofactories for high value-added compounds following application of a wide range of biotechnological tools. In particular, the conversion of nonfood crops into efficient biofactories is expected to be a strong asset in the development of a sustainable bioeconomy. The ‘nonfood’ status combined with the high metabolic versatility and the capacity of high-yield cultivation highlight the plant genus Nicotiana as one of the most appropriate ‘chassis’ f...
2 CitationsSource
#1Yann DevosH-Index: 16
#2Michael B. Bonsall (University of Oxford)H-Index: 51
Last. Ernst A. Wimmer (GAU: University of Göttingen)H-Index: 42
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Risk assessors, risk managers, developers, potential applicants, and other stakeholders at many levels discuss the need for new or further risk assessment guidance for deliberate environmental releases of gene drive-modified organisms. However, preparing useful and practical guidance entails challenges, to which we offer recommendations based on our experience drafting guidance.
2 CitationsSource
#1Parth Chansoria (UNC: University of North Carolina at Chapel Hill)
#2Emma L. Etter (UNC: University of North Carolina at Chapel Hill)
Last. Juliane Nguyen (UNC: University of North Carolina at Chapel Hill)
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The regeneration of dynamic organs remains challenging because they are intrinsically anisotropic and undergo large volumetric deformation during normal or pathological function. This hampers the durability and applicability of regenerative medicine approaches. To address the challenges of organ dynamics, a new class of patches have emerged with anisotropic and auxetic properties that mimic native tissue biomechanics and accommodate volumetric deformation. Here, we outline the critical design, m...
1 CitationsSource
#1Matthias W. Laschke (Saarland University)H-Index: 52
#2Michael D. Menger (Saarland University)H-Index: 91
Tissue regeneration is crucially dependent on sufficient vascularization. In regenerative medicine, this can be effectively achieved by autologous vascularization strategies using the body's own resources. These strategies include the administration of blood-derived factor preparations, adipose tissue-based vascularization, and the in situ engineering of vascularized tissue. Due to their simplicity, the translation of these strategies into clinical practice is easier in terms of feasibility, saf...
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#1Adam M. Beitz (MIT: Massachusetts Institute of Technology)H-Index: 1
#2Conrad G. Oakes (MIT: Massachusetts Institute of Technology)
Last. Kate E. Galloway (MIT: Massachusetts Institute of Technology)H-Index: 4
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Within mammalian systems, there exists enormous opportunity to use synthetic gene circuits to enhance phenotype-based drug discovery, to map the molecular origins of disease, and to validate therapeutics in complex cellular systems. While drug discovery has relied on marker staining and high-content imaging in cell-based assays, synthetic gene circuits expand the potential for precision and speed. Here we present a vision of how circuits can improve the speed and accuracy of drug discovery by en...
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#1Sasan Jalili-Firoozinezhad (MIT: Massachusetts Institute of Technology)H-Index: 1
#1Sasan Jalili-Firoozinezhad (MIT: Massachusetts Institute of Technology)H-Index: 14
Last. Joaquim M. S. Cabral (IST: Instituto Superior Técnico)H-Index: 76
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Animals often fail to faithfully mimic human diseases and drug toxicities, and most in vitro models are not complex enough to recapitulate human body function and pathophysiology. Organ-on-chip culture technology, however, offers a promising tool for the study of tissue development and homeostasis, which has brought us one step closer to performing human experimentation in vitro. To recapitulate the complex functionality of multiple organs at once, their respective on-chip models can be linked t...
2 CitationsSource
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