Review of the relationships among polysaccharides, gut microbiota, and human health.

Published on Feb 1, 2021in Food Research International4.972
· DOI :10.1016/J.FOODRES.2020.109858
Qianqian Song8
Estimated H-index: 8
(NCU: Nanchang University),
Yikun Wang1
Estimated H-index: 1
(NCU: Nanchang University)
+ 5 AuthorsJianhua Xie35
Estimated H-index: 35
(NCU: Nanchang University)
As a complex ecosystem of the human body, the intestinal flora maintains a dynamic balance with the host and plays an irreplaceable role in life activities such as nutritional metabolism and host immunity. The intestinal flora interacts with polysaccharides, the intestinal flora digests non-digestible polysaccharides, and polysaccharides can be used as an important energy source for intestinal microorganisms. Disturbance of the gut microbiota (GM) leads to the occurrence of diseases, polysaccharides as prebiotics can improve the disease by regulating the composition of GM. In this paper, we reviewed the current knowledge about the relationship between polysaccharides, gut microbiota, and and human health, described the microbial composition of the human, the relationship between intestinal flora disorders and disease occurrence, and summarized the interactions between polysaccharides and intestinal microorganisms.
#1Hao Wu (University of Gothenburg)H-Index: 108
#2Valentina Tremaroli (University of Gothenburg)H-Index: 31
Last. Fredrik Bäckhed (Health Science University)H-Index: 92
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Summary The link between the gut microbiota and type 2 diabetes (T2D) warrants further investigation because of known confounding effects from antidiabetic treatment. Here, we profiled the gut microbiota in a discovery (n = 1,011) and validation (n = 484) cohort comprising Swedish subjects naive for diabetes treatment and grouped by glycemic status. We observed that overall gut microbiota composition was altered in groups with impaired glucose tolerance, combined glucose intolerance and T2D, but...
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#1Giulia Bonfiglio (Sapienza University of Rome)H-Index: 4
#2Bruna Neroni (Sapienza University of Rome)H-Index: 4
Last. Serena Schippa (Sapienza University of Rome)H-Index: 26
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The gut microbiota is a complex microbial ecosystem that coexists with the human organism in the intestinal tract. The members of this ecosystem live together in a balance between them and the host, contributing to its healthy state. Stress, aging, and antibiotic therapies are the principal factors affecting the gut microbiota composition, breaking the mutualistic relationship among microbes and resulting in the overgrowth of potential pathogens. This condition, called dysbiosis, has been linked...
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#3Zhang Bin (SCUT: South China University of Technology)
Abstract A novel polysaccharide, designated as MOP-3, was extracted and isolated from the leaves of Moringa oleifera. Structural characterization showed that MOP-3 had a molecular weight (MW) of 4.033 × 106 Da and was composed of arabinose, glucose and galactose with a molar ratio of 47.73:1.00:57.65. Methylation and nuclear magnetic resonance (NMR) analysis revealed that the main glycosidic linkage types of MOP-3 were (1→3,6)-β-D-Galp, (1→6)-β-D-Galp, (1→5)-α-L-Araf, and T-α-L-Araf. MOP-3 conta...
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#2Monika Szulińska (Poznan University of Medical Sciences)H-Index: 16
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The gut microbiota (GM) is defined as the community of microorganisms (bacteria, archaea, fungi, viruses) colonizing the gastrointestinal tract. GM regulates various metabolic pathways in the host, including those involved in energy homeostasis, glucose and lipid metabolism, and bile acid metabolism. The relationship between alterations in intestinal microbiota and diseases associated with civilization is well documented. GM dysbiosis is involved in the pathogenesis of diverse diseases, such as ...
43 CitationsSource
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#2Han Bangxing (Anda: Anhui University)H-Index: 6
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Abstract A simple, rapid, and sensitive ultra-high performance liquid chromatography with charged aerosol detector (UPLC-CAD) method was developed for firstly simultaneous determination of seven oligosaccharides, including two pairs of linear oligosaccharides isomers (DP3-1, DP3-2 and DP4-1, DP4-2) and 3 high branched oligosaccharides (DP 5, 6 and 7), as well as sucrose in Pseudostellaria heterophylla. The separation was performed on a Waters BEH Amide column (2.1 × 150 mm i.d., 1.7 μm) with gra...
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#2Qiang Yu (NCU: Nanchang University)H-Index: 21
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#1Qingying Fang (NCU: Nanchang University)H-Index: 3
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33 CitationsSource
#1Quantao Ma (Beijing University of Chinese Medicine)H-Index: 4
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Abstract Type 2 diabetes mellitus (T2DM) is a common clinical chronic disease, while its pathogenesis is still inconclusive. Intestinal flora, the largest micro-ecological system in the human body, is involved in, meanwhile has a major impact on the body's material and energy metabolism. Recent studies have shown that in addition to obesity, genetics, and islet dysfunction, the disturbance of intestinal flora may partly give rise to diabetes. In this paper, we summarized the current research on ...
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Abstract Trillions of microbes have evolved with and continue to live on human beings. With the rapid advances in tools and technology in recent years, new knowledge and insight in cross-talk between the microbes and their hosts have gained. It is the aim of this work to critically review and summarize recent literature reports on the role of microbiota and mechanisms involved in the progress and development of major human diseases, which include obesity, hypertension, cardiovascular disease, di...
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Cited By13
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