Original paper
Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes
Abstract
Background and aims The reduced action of incretin hormones in type 2 diabetes (T2D) is mainly attributed to GIP insensitivity, but efficacy estimates of GIP and GLP-1 differ among studies, and the negligible effects of pharmacological GIP doses remain unexplained. We aimed to characterize incretin action in vivo in subjects with normal glucose tolerance (NGT) or T2D and provide an explanation for the different insulinotropic activity of GIP and...
Paper Details
Title
Different mechanisms of GIP and GLP-1 action explain their different therapeutic efficacy in type 2 diabetes
Published Date
Jan 1, 2021
Journal
Volume
114
Pages
154415 - 154415
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Notes
History