Original paper
Cerebral small vessel disease genomics and its implications across the lifespan
Abstract
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young...
Paper Details
Title
Cerebral small vessel disease genomics and its implications across the lifespan
Published Date
Dec 8, 2020
Journal
Volume
11
Issue
1
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History