Radiomics Analysis of 3D Dose Distributions to Predict Toxicity of Radiotherapy for Cervical Cancer

Dose-volume histograms (DVH) do not account for the spatial distributions of dose at the voxel level. Our goal was to compare the prediction of toxicity events after radiotherapy for locally advanced cervical cancer (LACC), relying on either DVH parameters or the use of the radiomics approach applied to dose maps at the voxel level. Acute and late toxicity scores using the CTCAE v4, spatial dose distributions, and usual clinical predictors for...