Focused kV X-rays for Preclinical Studies of Radiation-based Neuromodulation

Clinical observations suggest that precisely targeted irradiation can alter local neuronal function without neuronal destruction. The advancement of functional brain imaging has revealed regions of hypermetabolism that correlate with psychiatric illnesses. Radiation-based neuromodulation may offer an optimal tool to downregulate the hypermetabolic foci while preserving basic nerve functions. Achieving reliable radiomodulation in the absence of...