Original paper
ONC201 and imipridones: Anti-cancer compounds with clinical efficacy
Abstract
ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. ONC201 appears to act as a selective antagonist of the G protein coupled receptor (GPCR) dopamine receptor D2 (DRD2), and as an allosteric agonist of mitochondrial protease caseinolytic protease P (ClpP). Downstream of target engagement, ONC201 activates the ATF4/CHOP-mediated integrated stress response leading to TRAIL/Death Receptor 5...
Paper Details
Title
ONC201 and imipridones: Anti-cancer compounds with clinical efficacy
Published Date
Dec 1, 2020
Journal
Volume
22
Issue
12
Pages
725 - 744
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Notes
History