Autotaxin in ascites promotes peritoneal dissemination in pancreatic cancer
Abstract
Peritoneal dissemination and malignant ascites in pancreatic ductal adenocarcinoma (PDAC) patients represent a major clinical issue. Lysophosphatidic acid (LPA) is a lipid mediator that modulates the progression of various cancers. Based on the increasing evidence showing that LPA is abundant in malignant ascites, we focused on autotaxin (ATX), which is a secreted enzyme that is important for the production of LPA. This study aimed to elucidate...
Paper Details
Title
Autotaxin in ascites promotes peritoneal dissemination in pancreatic cancer
Published Date
Dec 21, 2020
Journal
Volume
112
Issue
2
Pages
668 - 678
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