Original paper

Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells

eLife6.40
Volume: 9
Published: Oct 12, 2020
Abstract
Tissue resident mesenchymal stem/stromal cells (MSCs) occupy perivascular spaces. Profiling human adipose perivascular mesenchyme with antibody arrays identified 16 novel surface antigens, including endolysosomal protein CD107a. Surface CD107a expression segregates MSCs into functionally distinct subsets. In culture, CD107alow cells demonstrate high colony formation, osteoprogenitor cell frequency, and osteogenic potential. Conversely,...
Paper Details
Title
Lysosomal protein surface expression discriminates fat- from bone-forming human mesenchymal precursor cells
Published Date
Oct 12, 2020
Journal
Volume
9
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