Internal medicine

Radiology

Glutamate carboxypeptidase II

Prostate cancer

Prostate-specific antigen

Positron Emission Tomography-Computed Tomography

Nuclear medicine

Cancer

Positron emission tomography

Radiation therapy

Medicine

European Urology Focus

Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is a novel, highly sensitive and specific imaging test that has significant promise for guiding radiotherapy for prostate cancer. Prospective evidence exists to inform the use of PSMA PET in patients with newly diagnosed localized disease, biochemical recurrence after radical prostatectomy, and oligometastatic disease. Numerous prospective phase 2/3 studies are ongoing to further evaluate the value of PSMA-guided radiotherapy.

Prostate-specific Membrane Antigen Positron Emission Tomography–guided Radiotherapy