Effect of α2-Adrenergic Receptor Stimulation on the Isolated Rat Heart against the Background of If Blockade
Volume: 169, Issue: 5, Pages: 635 - 638
Published: Sep 1, 2020
Abstract
The study examined the effect of α2-adrenoreceptor (α2-AR) activation against the background of preliminary blockage of If on the performance of Langerndorff-isolated rat heart. Stimulation of α2-AR in isolated rat hearts against the background of ZD7288 in concentrations of 10-9 M and 3×10-5 M changed the negative dynamics of myocardial inotropy to positive (by 25 and 38%; p<0.05). Activation of α2-AR produced opposite effects on HR. If...
Paper Details
Title
Effect of α2-Adrenergic Receptor Stimulation on the Isolated Rat Heart against the Background of If Blockade
Published Date
Sep 1, 2020
Volume
169
Issue
5
Pages
635 - 638
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