Timur L. Zefirov
Kazan Federal University
Hyperpolarization (biology)EndocrinologyInotropeChronotropicCardiologyReceptorChemistryStimulationHypokinesiaBradycardiaHeart rateBlockadeVagotomyAgonistVagus nerveContractilityAdrenergic receptorMedicineStroke volumeBlood pressure
66Publications
5H-index
105Citations
Publications 53
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#1Timur L. Zefirov (Kazan: Kazan Federal University)H-Index: 5
#2I. I. Khabibrakhmanov (Kazan: Kazan Federal University)H-Index: 1
Last. Andrey L. Zefirov (KSMU: Kazan State Medical University)H-Index: 17
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#1N. I. Ziyatdinova (Kazan: Kazan Federal University)H-Index: 4
#2A. M. Kuptsova (Kazan: Kazan Federal University)H-Index: 1
Last. Timur L. Zefirov (Kazan: Kazan Federal University)H-Index: 5
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#1I. I. Khabibrakhmanov (Kazan: Kazan Federal University)H-Index: 1
#2N. I. Ziyatdinova (Kazan: Kazan Federal University)H-Index: 4
Last. Timur L. Zefirov (Kazan: Kazan Federal University)H-Index: 5
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#1N. I. ZiyatdinovaH-Index: 4
#2A. M. KuptsovaH-Index: 1
Last. Timur L. ZefirovH-Index: 5
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The autonomic nervous system is involved in the regulation and formation of the heart rhythm. Most experimental studies about the influence of the autonomic nervous system on heart activity in ontogenesis were carried out on a whole organism or isolated tissue. An isolated heart by Langendorff can study arrhythmia, coronary vascular function, and can also help to understand the pathophysiology of modern human diseases, such as hypertension, diabetes, heart failure, or ischemia / reperfusion inju...
#1A. A. Zverev (Kazan: Kazan Federal University)H-Index: 2
#2T. A. Anikina (Kazan: Kazan Federal University)H-Index: 3
Last. Timur L. Zefirov (Kazan: Kazan Federal University)H-Index: 5
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The effects of neuropeptide Y (10—9-10—6 M) on electrical activity of right atrial cardiomyocytes of rats aging 7, 21, and 100 days were examined in vitro. Neuropeptide Y affected the amplitude-temporal parameters of the action potential in these cells. It decreased the duration of repolarization phase in 7-day-old rats in concentrations of 10—8 and 10—7 M, in 21-day-old rats at 10—8 and 10—6 M, and in 100-day-old at 10—6 M. The data indicate elevation of total membrane potassium current under t...
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#1Timur L. Zefirov (Kazan: Kazan Federal University)H-Index: 5
#2L. I. Faskhutdinov (Kazan: Kazan Federal University)H-Index: 1
Last. Andrey L. Zefirov (KSMU: Kazan State Medical University)H-Index: 17
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: The study examined the effect of clonidine hydrochloride (10-9-10-5 М) on electrical activity of working cardiomyocytes in rat right atrium. Stimulation of α2-adrenergic receptor with clonidine changed electrical activity of the heart. All tested concentrations of the agonist lengthened the action potential and decreased the firing rate of cardiomyocytes in a dose-dependent manner. The maximum effects of clonidine were observed at concentration of 10-5 М.
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#1N. I. Ziyatdinova (Kazan: Kazan Federal University)H-Index: 4
#2A. M. Kuptsova (Kazan: Kazan Federal University)H-Index: 1
Last. Timur L. Zefirov (Kazan: Kazan Federal University)H-Index: 5
view all 6 authors...
The study examined the effects of hyperpolarization-activated funny current (If) on HR and coronary flow in Langendorff-isolated hearts from newborn rats. Blockade of If current with ZD7288 changed the examined cardiac parameters. The blocker in a concentration of 10—9 M decreased HR by 26.8% (p≤0.05). In concentrations 10—8, 10—7, 10—6, and 10—5 M ZD7288 produced minor differently directed effects. In a concentration of 10—5 M, ZD7288 reduced coronary flow in the isolated heart (p≤0.01). In oth...
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