Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study

Published on Dec 15, 2020in American Journal of Respiratory and Critical Care Medicine21.405
· DOI :10.1164/RCCM.202007-2794OC
Thomas M Drake19
Estimated H-index: 19
(Edin.: University of Edinburgh),
Annemarie B Docherty22
Estimated H-index: 22
(Edin.: University of Edinburgh)
+ 68 AuthorsElisabeth Bendstrup28
Estimated H-index: 28
(Aarhus University Hospital)
Rationale: The impact of coronavirus disease (COVID-19) on patients with interstitial lung disease (ILD) has not been established.Objectives: To assess outcomes in patients with ILD hospitalized fo...
Abstract Background Hydroxychloroquine and azithromycin have been used to treat patients with coronavirus disease 2019 (Covid-19). However, evidence on the safety and efficacy of these therapies is...
#1Peter M. George (NIH: National Institutes of Health)H-Index: 65
#2Athol U. Wells (NIH: National Institutes of Health)H-Index: 120
Last. R. Gisli Jenkins (NIHR: National Institute for Health Research)H-Index: 5
view all 3 authors...
Summary In December, 2019, reports emerged from Wuhan, China, of a severe acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). By the end of April, 2020, over 3 million people had been confirmed infected, with over 1 million in the USA alone, and over 215 000 deaths. The symptoms associated with COVID-19 are diverse, ranging from mild upper respiratory tract symptoms to severe acute respiratory distress syndrome. The major risk factors for severe COVI...
#1Noriyuki Enomoto (Hamamatsu University)H-Index: 28
#2Hyogo Naoi (Hamamatsu University)H-Index: 2
Last. Takafumi Suda (Hamamatsu University)H-Index: 60
view all 14 authors...
Background:Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is well known as a life-threatening condition during its clinical course. However, the clinical features and prognosis in AE ...
Summary Background Over 40 000 patients with COVID-19 have been hospitalised in New York City (NY, USA) as of April 28, 2020. Data on the epidemiology, clinical course, and outcomes of critically ill patients with COVID-19 in this setting are needed. Methods This prospective observational cohort study took place at two NewYork-Presbyterian hospitals affiliated with Columbia University Irving Medical Center in northern Manhattan. We prospectively identified adult patients (aged ≥18 years) admitte...
#1David R. BoulwareH-Index: 57
#2Matthew F PullenH-Index: 10
Last. Kathy H. Hullsiek (McGill University)H-Index: 1
view all 24 authors...
Abstract Background Coronavirus disease 2019 (Covid-19) occurs after exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For persons who are exposed, the standard of care is o...
#1Amitava Banerjee (UCL: University College London)H-Index: 61
#2Laura Pasea (UCL: University College London)H-Index: 10
Last. Harry Hemingway (UCL: University College London)H-Index: 89
view all 16 authors...
Summary Background The medical, societal, and economic impact of the coronavirus disease 2019 (COVID-19) pandemic has unknown effects on overall population mortality. Previous models of population mortality are based on death over days among infected people, nearly all of whom thus far have underlying conditions. Models have not incorporated information on high-risk conditions or their longer-term baseline (pre-COVID-19) mortality. We estimated the excess number of deaths over 1 year under diffe...
#1Annemarie B Docherty (Edin.: University of Edinburgh)H-Index: 22
#2Ewen M Harrison (Edin.: University of Edinburgh)H-Index: 39
Last. Isaric C InvestigatorsH-Index: 8
view all 25 authors...
Abstract Objective To characterise the clinical features of patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United Kingdom during the growth phase of the first wave of this outbreak who were enrolled in the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK) study, and to explore risk factors associated with mortality in hospital. Design Prospective observat...
#1Gaohong Sheng (HUST: Huazhong University of Science and Technology)H-Index: 3
#2Peng Chen (HUST: Huazhong University of Science and Technology)H-Index: 2
Last. Huilan Zhang (HUST: Huazhong University of Science and Technology)H-Index: 9
view all 9 authors...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic lung disease with a poor prognosis. Although many factors have been identified to possibly trigger or aggravate IPF, such as viral infection, the exact etiology of IPF remains unclear. Until now, there has been no systematic review to quantitatively assess the role of viral infection in IPF. Objective This meta-analysis aims to present a collective view on the relationship between viral infection and IPF....
#1Michael Kreuter (Heidelberg University)H-Index: 40
#2Markus Polke (Heidelberg University)H-Index: 4
Last. Elisabeth Bendstrup (Aarhus University Hospital)H-Index: 28
view all 31 authors...
Aim Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is an often deadly complication of IPF. No focused international guidelines for the management of AE-IPF exist. The aim of this international survey was to assess the global variability in prevention, diagnostic and treatment strategies for AE-IPF. Material and methods Pulmonologists with ILD expertise were invited to participate in a survey designed by an international expert panel. Results 509 pulmonologists from 66 countries res...
Cited By49
#1Catherine Entriken (UC: University of Cincinnati)
#2Timothy A. Pritts (UC: University of Cincinnati)H-Index: 36
With the projected increase in the geriatric patient population, it is of the utmost importance to understand and optimize conditions in the perioperative period to ensure the best surgical outcome. Age-associated changes in respiratory physiology affect the surgical management of geriatric patients. This review focuses on perioperative pulmonary management of elderly individuals. The physiological changes associated with aging include both physical and biochemical alterations that are detriment...
#1Lijuan Li (China-Japan Friendship Hospital)
#2Chulei Wang (China-Japan Friendship Hospital)
view all 5 authors...
Introduction. Patients with interstitial lung disease (ILD) who subsequently develop a viral infection have high rates of morbidity and mortality.Hypothesis/Gap Statement. Few large-scale epidemiological studies have investigated potential prognostic factors for morbidity and mortality in this patient group.Aim. To evaluate the risk factors for morbidity and mortality in hospitalized patients with ILD and viral infection, as well as the clinical characteristics.Methodology. This retrospective co...
A 79-year-old woman presented with a week-long history of shortness of breath. She had a background of idiopathic pulmonary fibrosis (IPF) which was stable and had not required any antifibrotic treatment. A month prior to this presentation, she was admitted with COVID-19 pneumonia, with maximal oxygen requirement of 2 L, but was discharged without need for supplemental oxygen. On readmission, she was found to have severe, rapidly progressive pulmonary fibrosis. After all precipitating causes wer...
#1Yatharth Ranjan ('KCL': King's College London)H-Index: 5
#2Malik Althobiani (UCL: University College London)H-Index: 2
Last. Amos Folarin ('KCL': King's College London)H-Index: 19
view all 8 authors...
Background null Chronic Lung disorders like Chronic obstructive pulmonary disease (COPD) and Idiopathic pulmonary fibrosis (IPF) are characterised by exacerbations which are a significant problem: unpleasant for patients, and sometimes severe enough to cause hospital admission (and therefore National Health Service (NHS) pressures) and death. Reducing the impact of exacerbations is very important. Moreover, due to the coronavirus disease (COVID-19) pandemic, the vulnerable populations with these...
#1Varalakshmi Velagacherla (Manipal University)
#2Akhil Suresh (Manipal University)H-Index: 4
Last. Usha Y. Nayak (Manipal University)H-Index: 20
view all 4 authors...
Nintedanib (N.T.B) is an orally administered tyrosine kinase inhibitor that has been approved recently by U.S.F.D.A for idiopathic pulmonary fibrosis (I.P.F) and systemic sclerosis-associated inter...
#1Kyung Soo Lee (SKKU: Sungkyunkwan University)H-Index: 74
#2Yu Mi Wi (SKKU: Sungkyunkwan University)
Severe COVID-19 is characterized by acute respiratory distress syndrome (ARDS)-like hyperinflammation and endothelial dysfunction, that can lead to respiratory and multi organ failure and death. Interstitial lung diseases (ILD) and pulmonary fibrosis confer an increased risk for severe disease, while a subset of COVID-19-related ARDS surviving patients will develop a fibroproliferative response that can persist post hospitalization. Autotaxin (ATX) is a secreted lysophospholipase D, largely resp...
#2Anil Mathew Philip (Mission Health System)
Last. Amos Lal (Mayo Clinic)H-Index: 17
view all 7 authors...
Background null In the setting of the current pandemic, concerns have arisen regarding the multisystemic involvement of sarcoidosis and the possible exacerbations in response to the exposure to severe acute respiratory syndrome coronavirus 2. null Aim null This study aims to compare the differences in clinical presentation, management, and outcome of coronavirus disease 2019 (COVID-19) between patients with sarcoidosis and those in the general population. null Methods null A literature search wa...
Autotaxin (ATX; ENPP2) is a secreted lysophospholipase D catalyzing the extracellular production of lysophosphatidic acid (LPA), a pleiotropic signaling phospholipid. Genetic and pharmacologic studies have previously established a pathologic role for ATX and LPA signaling in pulmonary injury, inflammation, and fibrosis. Here, increased ENPP2 mRNA levels were detected in immune cells from nasopharyngeal swab samples of COVID-19 patients, and increased ATX serum levels were found in severe COVID-1...
#1Lichen Ouyang (Jianghan University)H-Index: 1
#2Jie Gong (HUST: Huazhong University of Science and Technology)H-Index: 1
Last. Muqing Yu (HUST: Huazhong University of Science and Technology)H-Index: 1
view all 3 authors...
BACKGROUND The impact of pre-existing interstitial lung disease (ILD) on the severity and mortality of COVID-19 remains largely unknown. The purpose of this meta-analysis was to investigate the prevalence of ILD among patients with COVID-19 and figure out the relationship between ILD and the poor clinical outcomes of COVID-19. METHODS A systematic literature search was conducted in the PubMed, EMBASE, Web of Science and MedRxiv Database from 1 January 2020 to 26 May 2021. RESULTS 15 studies with...
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.