Original paper
MBD2 Mediates Septic AKI through Activation of PKCη/p38MAPK and the ERK1/2 Axis
Abstract
Our previous study demonstrated that the methyl-CpG-binding domain protein 2 (MBD2) mediates vancomycin (VAN)-induced acute kidney injury (AKI). However, the role and regulation of MBD2 in septic AKI are unknown. Herein, MBD2 was induced by lipopolysaccharide (LPS) in Boston University mouse proximal tubules (BUMPTs) and mice. For both in vitro and in vivo experiments, we showed that inhibition of MBD2 by MBD2 small interfering RNA (siRNA) and...
Paper Details
Title
MBD2 Mediates Septic AKI through Activation of PKCη/p38MAPK and the ERK1/2 Axis
Published Date
Sep 29, 2020
Volume
23
Pages
76 - 88