Original paper
PCSK9 and LRP5 in macrophage lipid internalization and inflammation
Abstract
Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. Low-density lipoprotein receptors (LDLR) play a critical role in regulating blood cholesterol levels by binding to and clearing LDLs from the circulation. The disruption of the interaction between proprotein convertase subtilisin/kexin 9 (PCSK9) and LDLR reduces blood cholesterol levels. It is not well known whether...
Paper Details
Title
PCSK9 and LRP5 in macrophage lipid internalization and inflammation
Published Date
Sep 29, 2020
Journal
Volume
117
Issue
9
Pages
2054 - 2068
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Notes
History