Original paper
A structure-based computational workflow to predict liability and binding modes of small molecules to hERG
Abstract
Off-target interactions of drugs with the human ether-à-go-go related gene 1 (hERG1) channel have been associated with severe cardiotoxic conditions leading to the withdrawal of many drugs from the market over the last decades. Consequently, predicting drug-induced hERG-liability is now a prerequisite in any drug discovery campaign. Understanding the atomic level interactions of drug with the channel is essential to guide the efficient...
Paper Details
Title
A structure-based computational workflow to predict liability and binding modes of small molecules to hERG
Published Date
Oct 1, 2020
Journal
Volume
10
Issue
1
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Notes
History