Shawn M. Lamothe
University of Alberta
Protein subunitPhysicsBiophysicsInternal medicineDownregulation and upregulationUbiquitin ligaseUnfolded protein responsePatch clampCardiologyNociceptorHEK 293 cellsProteasesChemistrySensitivity (control systems)Obstructive sleep apneaDisinhibitionNeuropathic painNEDD4ArrestinExperimental autoimmune encephalomyelitishERGHypoxia (medical)Long QT syndromeMultiple sclerosisExtracellularSudden deathIon channelCalpainBK channelMedicinePotassium channelBiologyCell biologyPharmacology
38Publications
8H-index
142Citations
Publications 37
Newest
#1Lance H. Rodan (Boston Children's Hospital)H-Index: 21
#2Rebecca C. Spillmann (Durham University)H-Index: 18
Last. O. Bar-Yosef (TAU: Tel Aviv University)H-Index: 7
view all 57 authors...
PURPOSE CACNA1C encodes the alpha-1-subunit of a voltage-dependent L-type calcium channel expressed in human heart and brain. Heterozygous variants in CACNA1C have previously been reported in association with Timothy syndrome and long QT syndrome. Several case reports have suggested that CACNA1C variation may also be associated with a primarily neurological phenotype. METHODS We describe 25 individuals from 22 families with heterozygous variants in CACNA1C, who present with predominantly neurolo...
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#1Shawn M. Lamothe (U of A: University of Alberta)H-Index: 8
#2Nazlee Sharmin (U of A: University of Alberta)H-Index: 3
Last. Harley T. Kurata (U of A: University of Alberta)H-Index: 21
view all 8 authors...
Many voltage-dependent ion channels are regulated by accessory proteins. We recently reported powerful regulation of Kv1.2 potassium channels by the amino acid transporter Slc7a5. In this study, we report that Kv1.1 channels are also regulated by Slc7a5, albeit with different functional outcomes. In heterologous expression systems, Kv1.1 exhibits prominent current enhancement ('disinhibition') with holding potentials more negative than -120 mV. Knockdown of endogenous Slc7a5 leads to larger Kv1....
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#1Jasmine Maghera (U of A: University of Alberta)H-Index: 3
#2Jingru Li (U of A: University of Alberta)H-Index: 3
Last. Harley T. Kurata (U of A: University of Alberta)H-Index: 21
view all 7 authors...
Objective A spectrum of seizure disorders is linked to mutations in Kv7.2 and Kv7.3 channels. Linking functional effects of identified mutations to their clinical presentation requires ongoing characterization of newly identified variants. In this study, we identified and functionally characterized a previously unreported mutation in the selectivity filter of Kv7.3. Methods Next-generation sequencing was used to identify the Kv7.3[T313I] mutation in a family affected by neonatal seizures. Electr...
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#1Subha Kalyaanamoorthy (UW: University of Waterloo)H-Index: 13
#2Shawn M. Lamothe (U of A: University of Alberta)H-Index: 8
Last. Khaled Barakat (U of A: University of Alberta)H-Index: 23
view all 7 authors...
Off-target interactions of drugs with the human ether-a-go-go related gene 1 (hERG1) channel have been associated with severe cardiotoxic conditions leading to the withdrawal of many drugs from the market over the last decades. Consequently, predicting drug-induced hERG-liability is now a prerequisite in any drug discovery campaign. Understanding the atomic level interactions of drug with the channel is essential to guide the efficient development of safe drugs. Here we utilize the recent cryo-E...
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#1Muhammad Saad Yousuf (U of A: University of Alberta)H-Index: 9
#2Samira Samtleben (U of A: University of Alberta)H-Index: 2
Last. Bradley J. Kerr (U of A: University of Alberta)H-Index: 29
view all 13 authors...
Neuropathic pain is a common symptom of multiple sclerosis (MS) and current treatment options are ineffective. In this study, we investigated whether endoplasmic reticulum (ER) stress in dorsal root ganglia (DRG) contributes to pain hypersensitivity in the experimental autoimmune encephalomyelitis (EAE) mouse model of MS. Inflammatory cells and increased levels of ER stress markers are evident in post-mortem DRGs from MS patients. Similarly, we observed ER stress in the DRG of mice with EAE and ...
Source
#1Shawn M. Lamothe (U of A: University of Alberta)H-Index: 8
#2Harley T. Kurata (U of A: University of Alberta)H-Index: 21
The voltage-gated potassium channel Kv1.2 plays a pivotal role in neuronal excitability and is regulated by a variety of known and unknown extrinsic factors. The canonical accessory subunit of Kv1.2, Kvbeta, promotes N-type inactivation and cell surface expression of the channel. We recently reported that a neutral amino acid transporter, Slc7a5, alters the function and expression of Kv1.2. In the current study, we investigated the effects of Slc7a5 on Kv1.2 in the presence of Kvbeta1.2 subunits...
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#1Motoyasu Satou (U of A: University of Alberta)H-Index: 2
#2Jason Wang (U of A: University of Alberta)H-Index: 1
Last. Toru Tateno (U of A: University of Alberta)H-Index: 15
view all 12 authors...
Abstract Pituitary tumors (PTs) can cause significant mortality and morbidity due to limited therapeutic options. L-type amino acid transporters (LATs), in particular, the LAT1 isoform, is expressed in a variety of tumor cells. Pharmacological inhibition or genetic ablation of LAT1 can suppress leucine transport into cancer cells, resulting in suppression of cancer cell growth. However, roles of LAT1 in PTs have not been elucidated. Therefore, we assessed LAT1 expression in PTs and evaluated a L...
Source
#1Muhammad Saad Yousuf (U of A: University of Alberta)H-Index: 9
#2Samira Samtleben (U of A: University of Alberta)H-Index: 2
Last. Bradley J. Kerr (U of A: University of Alberta)H-Index: 29
view all 13 authors...
Neuropathic pain is a common symptom of multiple sclerosis (MS) and current treatment options are ineffective. In this study, we investigated whether endoplasmic reticulum (ER) stress in dorsal root ganglia (DRG) contributes to pain hypersensitivity in the experimental autoimmune encephalomyelitis (EAE) mouse model of MS. Inflammatory cells and increased levels of ER stress markers are evident in post-mortem DRGs from MS patients. Similarly, we observed ER stress in the DRG of mice with EAE and ...
Source
#1Shawn M. Lamothe (U of A: University of Alberta)H-Index: 8
#2Nazlee Sharmin (U of A: University of Alberta)H-Index: 3
Last. Harley T. Kurata (U of A: University of Alberta)H-Index: 21
view all 8 authors...
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