A nationwide trend analysis in the incidence and mortality of Creutzfeldt-Jakob disease in Japan between 2005 and 2014.

Published on Sep 23, 2020in Scientific Reports3.998
· DOI :10.1038/S41598-020-72519-0
Yoshito Nishimura5
Estimated H-index: 5
(Okayama University),
Ko Harada3
Estimated H-index: 3
(Okayama University)
+ 2 AuthorsFumio Otsuka35
Estimated H-index: 35
(Okayama University)
Sources
Abstract
In the era of hyper-ageing, Creutzfeldt-Jakob disease (CJD) can become more prevalent as an important cause of dementia. This study aimed to evaluate the trends in crude and age-adjusted CJD-associated mortality and incidence rates in Japan using national vital statistics data on CJD-associated deaths among individuals aged over 50 years, as well as the government-funded nationwide CJD surveillance data (pertaining to the years 2005-2014) in Japan. The data were analysed using the Joinpoint Regression Program to estimate the long-term trends and average annual percentage changes (AAPCs). Overall, the AAPCs of age-adjusted CJD-associated mortality rates rose significantly over the study period (3.2%; 95% confidence interval [CI] 1.4-5.1%). The AAPC of the age-adjusted incidence rates also increased (overall 6.4%; 95% CI 4.7-8.1%). The CJD-associated increases in the mortality and incidence rates were especially prominent among adults over the age of 70 years. Given this trend in aging of population, the disease burden of CJD will continue to increase in severity. Our findings thus recommend that policymakers be aware of the importance of CJD and focus on preparing to address the increasing prevalence of dementia.
References23
Newest
#1Lesley Uttley (University of Sheffield)H-Index: 16
#2Christopher Carroll (University of Sheffield)H-Index: 51
Last. Mark Stevenson (University of Sheffield)H-Index: 86
view all 5 authors...
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26 CitationsSource
#1Hiroshi Matsumura (Japanese Ministry of Health, Labour and Welfare)H-Index: 1
#2Yoshito Nishimura (Okayama University)H-Index: 5
Last. Hideaki Nishizawa (Japanese Ministry of Health, Labour and Welfare)H-Index: 1
view all 6 authors...
The third G20 Health Ministers' Meeting was held in Okayama, Japan on October 19-20, 2019. The authors were involved in the decision making of the substantial issues of this meeting including theme setting, schedule management, facilitating the discussion, and preparation for the ministers' meeting. Here, we summarize our lessons of experience from hosting G20 Okayama Health Ministers' Meeting as: i) Utilizing the occasion of existing major health related meeting to gain efficiency; ii) Collabor...
6 CitationsSource
#1Genevieve M Klug (University of Melbourne)H-Index: 15
#2Alison Boyd (University of Melbourne)H-Index: 17
Last. Steven J. Collins (University of Melbourne)H-Index: 69
view all 8 authors...
Nationwide surveillance of human prion diseases (also known as transmissible spongiform encephalopathies), the most common being Creutzfeldt–Jakob disease (CJD), is performed by the Australian National Creutzfeldt–Jakob Disease Registry (ANCJDR), based at the University of Melbourne. National surveillance encompasses the period since 1970, with prospective surveillance occurring from 1993 onwards. Over this prospective surveillance period considerable developments have occurred, especially in re...
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#1Takayo Nakabe (Kyoto University)H-Index: 2
#2Noriko Sasaki (Kyoto University)H-Index: 7
Last. Yuichi Imanaka (Kyoto University)H-Index: 25
view all 6 authors...
Objective The purpose of this study was to clarify the microlevel determinants of the economic burden of dementia care at home in Japanese community settings by classifying them into subgroups of factors related to people with dementia and their caregivers. Design A cross-sectional online survey. Participants 4313 panels of Japanese research company who fulfilled the following criteria: (1) aged 30 years or older, (2) non-professional caregiver of someone with dementia, (3) caring for only one p...
4 CitationsSource
Objectives: An extraordinary incidence of genetic Creutzfeldt-Jakob disease (gCJD) appearing in clusters in the Slovak Republic was described in the 1990's. The aim of the study was to analyse data of CJD cases obtained from surveillance in Eastern Slovakia (ES) (2004-2016), the region outside the described geographical clusters. Methods: The database set in the project was the source for epidemiological and clinical analysis of CJD cases. Results: The incidence of CJD in ES (2004-2016) was 1.7/...
2 CitationsSource
#1Katsuya SatohH-Index: 24
#2Noriyuki NishidaH-Index: 28
Last. Susumu ShirabeH-Index: 24
view all 3 authors...
Source
#1Alice Uflacker (Duke University)H-Index: 3
#2Mary Edmondson (Duke University)H-Index: 7
Last. Brian S. Appleby (Case Western Reserve University)H-Index: 18
view all 4 authors...
Caregiver burden is a significant issue in the treatment of dementia and a known contributor to institutionalization of patients with dementia. Published data have documented increased caregiver burden in behavioral variant frontotemporal dementia (bvFTD) compared to Alzheimer's disease (AD). Another atypical dementia with high-perceived caregiver burden is sporadic Creutzfeldt-Jakob disease (sCJD), but no formal studies have assessed this perception. The aim of this study was to compare caregiv...
25 CitationsSource
#2Gerard H. JansenH-Index: 26
Last. Neil R. CashmanH-Index: 59
view all 11 authors...
Background: Human prion diseases, known collectively as Creutzfeldt-Jakob disease (CJD), are fatal, infectious neurodegenerative disorders that occur in all human populations. Objective: To summarize national surveillance data for CJD in Canada between January 1, 1998, and December 31, 2013. Methods: Detailed investigations were conducted of individual suspected CJD cases, with collaboration between Canadian health professionals and investigators affiliated with a central CJD surveillance regist...
8 CitationsSource
#1Jeongmin LeeH-Index: 8
#2Jae Wook HyeonH-Index: 7
Last. Chongsuk Ryou (Hanyang University)H-Index: 17
view all 6 authors...
Creutzfeldt–Jakob disease (CJD) is a representative human transmissible spongiform encephalopathy associated with central nervous system degeneration. Prions, the causative agents of CJD, are composed of misfolded prion proteins and are able to self-replicate. While CJD is a rare disease affecting only 1–1.5 people per million worldwide annually, it has attracted both scientific and public attention as a threatening disease since an epidemic of variant CJD (vCJD) cases appeared in the mid-1990s....
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The cellular prion protein (PrPC) has been widely investigated ever since its conformational isoform, the prion (or PrPSc), was identified as the etiological agent of prion disorders. The high homology shared by the PrPC-encoding gene among mammals, its high turnover rate and expression in every tissue strongly suggest that PrPC may possess key physiological functions. Therefore, defining PrPC roles, properties and fate in the physiology of mammalian cells would be fundamental to understand its ...
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Source
#1N.J. Watson (Edin.: University of Edinburgh)H-Index: 2
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Creutzfeldt–Jakob disease (CJD) is a rapidly progressive, fatal and transmissible neurodegenerative disease associated with the accumulation of misfolded prion protein in the CNS. International CJD surveillance programmes have been active since the emergence, in the mid-1990s, of variant CJD (vCJD), a disease linked to bovine spongiform encephalopathy. Control measures have now successfully contained bovine spongiform encephalopathy and the incidence of vCJD has declined, leading to questions ab...
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