Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin

Nature64.80
Volume: 585, Issue: 7826, Pages: 609 - 613
Published: Sep 16, 2020
Abstract
Breaks in DNA strands recruit the protein PARP1 and its paralogue PARP2 to modify histones and other substrates through the addition of mono- and poly(ADP-ribose) (PAR)1-5. In the DNA damage responses, this post-translational modification occurs predominantly on serine residues6-8 and requires HPF1, an accessory factor that switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutamate to serine9,10. Poly(ADP) ribosylation...
Paper Details
Title
Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin
Published Date
Sep 16, 2020
Journal
Volume
585
Issue
7826
Pages
609 - 613
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