Improving safety of cancer immunotherapy via delivery technology.

Published on Jan 1, 2021in Biomaterials10.317
· DOI :10.1016/J.BIOMATERIALS.2020.120407
Doudou Hu2
Estimated H-index: 2
(ZJU: Zhejiang University),
Wei Zhang20
Estimated H-index: 20
(ZJU: Zhejiang University)
+ 3 AuthorsYouqing Shen63
Estimated H-index: 63
(ZJU: Zhejiang University)
Abstract Breakthroughs in molecular mechanisms underlying immune-suppressive tumor microenvironment and paradigm shifts in the cancer-immunity response cycle have profoundly changed the landscape of cancer immunotherapy. However, one of the challenges is to mitigate the serious side effects caused by systemic autoimmunity and autoinflammatory responses following immunotherapy. Thus, restraining the activation of the immune system in healthy tissues is highly desirable to address this problem. Bioengineering and delivery technologies provide a solution to the issue. In this Review, we first introduce immune-related adverse effects of main immunotherapies and the underlying mechanisms, summarize various strategies to construct bioengineering and delivery systems in order to reduce their immunotoxicities, and highlight the importance for the development of immunotoxicity-related animal models.
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