Original paper
Structural basis of nucleosome-dependent cGAS inhibition
Abstract
Saving a host cell from itself A fundamental mammalian defense mechanism against pathogens and damaged cellular DNA is to recognize DNA fragments in the cytosol and trigger an inflammatory response. The cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) that recognizes cytosolic DNA is also found in the nucleus, but here its activity is suppressed by tethering to chromatin. Two papers now report cryo–electron microscopy...
Paper Details
Title
Structural basis of nucleosome-dependent cGAS inhibition
Published Date
Oct 23, 2020
Journal
Volume
370
Issue
6515
Pages
450 - 454
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Notes
History