Rapid Screening of Urinary 1-Hydroxypyrene Glucuronide by Multisegment Injection–Capillary Electrophoresis–Tandem Mass Spectrometry: A High-Throughput Method for Biomonitoring of Recent Smoke Exposures

Urinary 1-hydroxypyrene (HP) is a widely used biomarker of polycyclic aromatic hydrocarbon exposure relevant for biomonitoring the deleterious health impacts from tobacco smoke and ambient air pollution, as well as the hazards of certain occupations. Conventional methods for urinary HP analysis based on liquid chromatography with native fluorescence detection or tandem mass spectrometry (MS/MS) and gas chromatography–mass spectrometry (GC–MS)...