Absence of CCR3 receptor accelerates atherosclerosis in apoE-/- mice

Introduction: Atherosclerosis is one of the leading causes of morbidity and mortality in Western countries and bears several histopathologic similarities to chronic inflammation. The early atherosclerotic lesion involves an inflammatory response consisting in the intimal accumulation of T lymphocytes and lipid-laden macrophages, and these events occur continuously throughout the entire atherogenic process. Eotaxin-1 (CCL11) expression has been...