Aida Collado
University of Valencia
CytotoxicityPattern recognition receptorAngiotensin II receptor type 1Internal medicinePeroxisomeRetinoid X receptorTransactivationChemokineEndocrinologyCXCL16Peripheral blood mononuclear cellCCR3Vascular endothelial growth factor AProinflammatory cytokineReceptorSTAT proteinCalcitriol receptorTumor necrosis factor alphaKnockout mouseChemistryStructure–activity relationshipImmunologyCCR2In silicoTLR4CalcitriolSTAT2Systemic inflammationBenzopyranCOPDInflammationEndotheliumSTAT1Vascular endothelial growth factorRHOACholesterolPostprandialstatUnsaturated fatCytokineAortic ruptureSTAT3Abdominal aortic aneurysmLipoproteinLosartanEndothelial dysfunctionMonocyteIntravital microscopyAngiotensin IIPrimary hypercholesterolemiaVitamin D3 ReceptorDissecting Abdominal Aortic AneurysmSodium/Glucose Cotransporter 2Apoe miceGlucose homeostasisPlatelet activationCancer researchApolipoprotein EPrenylationMedicineBiologyPlateletPharmacology
13Publications
6H-index
110Citations
Publications 13
Newest
#1Aida Collado (University of Valencia)H-Index: 6
#2Elena Domingo (University of Valencia)H-Index: 3
Last. Maria-Jesus Sanz (University of Valencia)H-Index: 27
view all 4 authors...
Primary hypercholesterolemia, a metabolic disorder characterized by elevated circulating levels of cholesterol products, mainly low-density lipoproteins, is associated with arteriosclerosis development. Cardiovascular disease, predominantly myocardial infarction and stroke, remains the main cause of death worldwide, with atherosclerosis considered to be the most common underlying pathology. In addition to elevated plasma levels of low-density lipoproteins, low-grade systemic inflammation and end...
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#1Aida ColladoH-Index: 6
#2Elena DomingoH-Index: 3
Last. Maria-Jesus SanzH-Index: 27
view all 9 authors...
Context: Primary hypercholesterolemia (PH) is a lipid disorder characterized by elevated levels of cholesterol and low-density lipoprotein (LDL). Low-grade systemic inflammation is associated with PH, which might explain the higher incidence of cardiovascular diseases in this setting. Objective: To evaluate the effect of an oral unsaturated fat load (OUFL) on different immune parameters and functional consequences in patients with PH in postprandial state. Design: A commercial liquid preparation...
1 CitationsSource
#1Rebeca OrtegaH-Index: 3
#2Aida ColladoH-Index: 6
Last. Laura Piqueras (University of Valencia)H-Index: 21
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Objective: Abdominal aortic aneurysm (AAA) is a pathological condition of permanent vessel dilatation that predisposes to the potentially fatal consequence of aortic rupture. SGLT-2 (sodium-glucose...
21 CitationsSource
#1Almudena Bermejo (University of Valencia)H-Index: 21
#2Aida Collado (University of Valencia)H-Index: 6
Last. Diego Cortes (University of Valencia)H-Index: 30
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Dual peroxisome proliferator-activated receptor-α/γ (PPARα/γ) agonists regulate both lipid and glucose homeostasis under different metabolic conditions and can exert anti-inflammatory activity. We investigated the potential dual PPARα/γ agonism of prenylated benzopyrans polycerasoidol (1) and polycerasoidin (2) and their derivatives for novel drug development. Nine semisynthetic derivatives were prepared from the natural polycerasoidol (1) and polycerasoidin (2), which were evaluated for PPARα, ...
5 CitationsSource
#1Patrice Marques (University of Valencia)H-Index: 5
#2Aida Collado (University of Valencia)H-Index: 6
Last. Maria-Jesus Sanz (University of Valencia)H-Index: 27
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Background: Metabolic syndrome is associated with low-grade systemic inflammation, which is a key driver of premature atherosclerosis. We characterized immune cell behavior in metabolic syndrome, its consequences, and the potential involvement of the CX3CL1/CX3CR1 and CCL2/CCR2 chemokine axes. Methods: Whole blood from 18 patients with metabolic syndrome and 21 age-matched controls was analyzed by flow cytometry to determine the leukocyte immunophenotypes, activation, platelet-leukocyte aggregat...
14 CitationsSource
#1Aida Collado (University of Valencia)H-Index: 6
#2Patrice Marques (University of Valencia)H-Index: 5
Last. Maria-Jesus Sanz (University of Valencia)H-Index: 27
view all 10 authors...
Primary hypercholesterolemia (PH) is associated with a low grade systemic inflammation that is likely the main driver of premature atherosclerosis. Accordingly, we characterized the immune cell behaviour in PH and its potential consequences. Whole blood from 22 PH patients and 21 age-matched controls was analysed by flow cytometry to determine the percentage of leukocyte immunophenotypes, activation, and platelet-leukocyte aggregates. Plasma markers were determined by Enzyme-Linked ImmunoSorbent...
8 CitationsSource
#1Aida Collado (University of Valencia)H-Index: 6
#2Patrice Marques (University of Valencia)H-Index: 5
Last. Maria-Jesus Sanz (University of Valencia)H-Index: 27
view all 10 authors...
Aims: Angiotensin-II (Ang-II) is the main effector peptide of the renin-angiotensin system (RAS) and promotes leucocyte adhesion to the stimulated endothelium. Because RAS activation and Ang-II signalling are implicated in metabolic syndrome (MS) and abdominal aortic aneurysm (AAA), we investigated the effect of Ang-II on CXCL16 arterial expression, the underlying mechanisms, and the functional role of the CXCL16/CXCR6 axis in these cardiometabolic disorders. Methods and results: Results from in...
16 CitationsSource
#1Martyna Plens-Galaska (Adam Mickiewicz University in Poznań)H-Index: 2
#2Malgorzata Szelag (Adam Mickiewicz University in Poznań)H-Index: 7
Last. Hans A.R. Bluyssen (Adam Mickiewicz University in Poznań)H-Index: 28
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Cardiovascular diseases (CVDs), including atherosclerosis, are globally the leading cause of death. Key factors contributing to onset and progression of atherosclerosis include the pro-inflammatory cytokines Interferon (IFN)α and IFNγ and the Pattern Recognition Receptor (PRR) Toll-like receptor 4 (TLR4). Together, they trigger activation of Signal Transducer and Activator of Transcription (STAT)s. Searches for compounds targeting the pTyr-SH2 interaction area of STAT3, yielded many small molecu...
2 CitationsSource
#1Aida Collado (University of Valencia)H-Index: 6
#2Patrice MarquesH-Index: 5
Last. Maria-Jesus Sanz (University of Valencia)H-Index: 27
view all 8 authors...
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#1María José Sanz (University of Valencia)H-Index: 52
#2Aida Collado (University of Valencia)H-Index: 6
Last. Juan F. AscasoH-Index: 29
view all 9 authors...
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