Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation

Published on Sep 4, 2020in Chemistry of Materials9.811
· DOI :10.1021/ACS.CHEMMATER.0C02911
Tomáš Sedlačík1
Estimated H-index: 1
Takayuki Nonoyama24
Estimated H-index: 24
+ 5 AuthorsJian Ping Gong81
Estimated H-index: 81
Supermacroporous hydrogels, possessing sponge-like structure and permeability, have drawn significant attention for their bioengineering and biomedical applications. However, their mechanical weakn...
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Hydrogels are tridimensional networks that are able to retain important amounts of water. These soft materials can be obtained through self-assembling processes involving either hydrophilic molecules or polymers, allowing the formation of the corresponding covalently and physically cross-linked networks. Although the applicability of hydrogels in biomedicine has been exponentially growing due to their biocompatibility and different responses to stimuli, these materials have exhibited the particu...
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#1Liju Xu (CAS: Chinese Academy of Sciences)H-Index: 4
#2Chen Wang (CAS: Chinese Academy of Sciences)H-Index: 39
Last. Dong Qiu (CAS: Chinese Academy of Sciences)H-Index: 27
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Hydrogels from biological sources are expected as potential structural biomaterials, but most of them are either soft or fragile. Here, a new strategy was developed to construct hydrogels that were both stiff and tough via the formation of the conjoined-network, which was distinct from improving homogeneity or incorporating energy dissipation mechanisms (double-network) approaches. Conjoined-network hydrogels stand for a class of hydrogels consisting of two or more networks that are connected by...
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Abstract In this review article we consider the crack growth resistance of micrometer and sub-micrometer sized samples from the fracture mechanics point of view. Standard fracture mechanics test procedures were developed for macro-scale samples, and reduction of the specimen dimensions by three to five orders of magnitude has severe consequences. This concerns the interpretation of results obtained by micro- and nano-mechanics, as well as the life time and failure prediction of micro- and nano-d...
#1Vladimir I. Lozinsky (A. N. Nesmeyanov Institute of Organoelement Compounds)H-Index: 43
A variety of cryogenically-structured polymeric materials are of significant scientific and applied interest in various areas. However, in spite of considerable attention to these materials and intensive elaboration of their new examples, as well as the impressive growth in the number of the publications and patents on this topic over the past two decades, a marked variability of the used terminology and definitions is frequently met with in the papers, reviews, theses, patents, conference prese...
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Last. Bruce P. Lee (MTU: Michigan Technological University)H-Index: 33
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A hydrogel is a three-dimensional polymer network with high water content and has been attractive for many biomedical applications due to its excellent biocompatibility. However, classic hydrogels are mechanically weak and unsuitable for most physiological load-bearing situations. Thus, the development of tough hydrogels used in the biomedical field becomes critical. This work reviews various strategies to fabricate tough hydrogels with the introduction of non-covalent bonds and the construction...
#1Lalit Kumar Meena (Central University of Gujarat)H-Index: 2
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Abstract Severe blood loss due to traumatic injuries remains one of the leading causes of death in emergency settings. Chitosan continues to be the candidate material for hemostatic applications due to its inherent hemostatic properties. However, available chitosan-based dressings have been reported to have an acidic odor at the wound site due to the incorporation of acid based solvents for their fabrication and deformation under compression owing to low mechanical strength limiting its usabilit...
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#2Michael S. Silverstein (Technion – Israel Institute of Technology)H-Index: 44
Double-network (DN) hydrogels are a combination of two very different polymer networks. Here, porous hydrogels with DN structures were successfully synthesized in two sequential free-radical polymerization steps. The first network was templated within a high internal phase emulsion (HIPE) to yield a hydrogel polyHIPE (HG-PH). The double network hydrogel polyHIPEs (DN-PHs) combined a more rigid highly crosslinked, polyelectrolyte (poly(2-acrylamido-2-methylpropanesulfonic acid), PAMPS) first netw...
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Last. Oguz Okay (ITU: Istanbul Technical University)H-Index: 61
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Abstract Mechanically strong silk fibroin cryogels with two generations of pores were produced by carrying out the cryogelation reactions within the pores of the initial single-network (SN) fibroin cryogels. In this way, cryogels with interpenetrated and interconnected double- (DN), and triple-network (TN) structures were produced from fibroin solutions frozen at −18 °C in the presence of butanediol diglycidyl ether cross-linker and N,N,N′,N′-tetramethylethylenediamine as a pH regulator. Cryogel...
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Abstract The extracellular matrix is fundamental in providing an appropriate environment for cell interaction and signaling to occur. Replicating such a matrix is advantageous in the support of tissue ingrowth and regeneration through the field of tissue engineering. While scaffolds can be fabricated in many ways, cryogels have recently become a popular approach due to their macroporous structure and durability. Produced through the crosslinking of gel precursors followed by a subsequent control...
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Macroporous polymeric gels has received great attention in many fields focused on biotechnological applications. In this study, two new HEMA-based cryogel columns were synthesized. To this end, poly(HEMA-VF) and poly(HEMA-NVP) cryogels were prepared by copolymerization of 2-Hydroxyethyl methacrylate (HEMA) with N-vinylformamide (VF) and N-vinylpyrrolidone (VP) in the presence of N,N-methylenebisacrylamide (as cross-linker), then polymerization initiated by ammonium persulfate (APS) and N,N,N′,N′...
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In a recent publication in Nature, He and co-workers reported an elegant strategy for the preparation of structurally organized porous hydrogels that are remarkably strong but extremely tough at the same time. The methodology combines approaches of molecular and structural engineering.
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