Jian Ping Gong
Hokkaido University
Self-healing hydrogelsBiophysicsPolyelectrolyteCopolymerComposite materialMonomerNanotechnologyCationic polymerizationAqueous solutionChemistryPolymer chemistryMaterials scienceSwellingDouble networkChemical engineeringFracture (geology)PolymerizationPolymerStress (mechanics)Toughness
512Publications
79H-index
19.1kCitations
Publications 491
Newest
#1Yun Zhou Guo (Hokkaido University)H-Index: 2
#2Tasuku Nakajima (Hokkaido University)H-Index: 35
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
view all 9 authors...
Abstract null null The extreme mechanical strength of fibrous connective tissues in the human body, such as ligaments and tendons, has always been challenging for hydrogel scientists. Here, we created extremely strong, purely cellulose-based hydrogels (DCC-E gels). The fracture stress and Young’s modulus of the gels were improved to the level of an Achilles tendon even at their equilibrium swollen state. To make DCC-E gels, regenerated cellulose gels were first prepared with ethanol as the anti-...
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#1Zezhou Liu (Cornell University)H-Index: 6
#2Chung-Yuen Hui (Hokkaido University)H-Index: 70
Last. Ryuji Kiyama (Hokkaido University)H-Index: 6
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When a poroelastic gel is released from a patterned mold, surface stress drives deformation and solvent migration in the gel and flattens its surface profile in a time-dependent manner. Specifically, the gel behaves like an incompressible solid immediately after removal from the mold, and becomes compressible as the solvent is able to squeeze out of the polymer network. In this work, we use the finite element method (FEM) to simulate this transient surface flattening process. We assume that the ...
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#1Tsuyoshi Okumura (Hokkaido University)H-Index: 1
#2Riku Takahashi (Hokkaido University)H-Index: 12
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
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We propose a new concept that utilizes the difference in Poisson's ratio between component materials as a strengthening mechanism that increases the effectiveness of the sacrificial bond toughening mechanism in macroscale double-network (Macro-DN) materials. These Macro-DN composites consist of a macroscopic skeleton imbedded within a soft elastic matrix. We varied the Poisson's ratio of the reinforcing skeleton by introducing auxetic or honeycomb functional structures that results in Poisson's ...
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#1Ya Nan Ye (Hokkaido University)H-Index: 6
#2Anamul Haque (Hokkaido University)H-Index: 2
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
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Soft and wet hydrogels have many similarities to biological tissues, though their mechanical fragility had been one of the biggest obstacles in biomedical applications. Studies and developments in double network (DN) hydrogels have elucidated how to create tough gels universally based on sacrificial bond principles and opened a path for biomedical application of hydrogels in regenerative medicine and artificial soft connective tissues, such as cartilage, tendon, and ligament, which endure high t...
2 CitationsSource
#1Liang Xu (Hokkaido University)H-Index: 2
#2Atsushi Urita (Hokkaido University)H-Index: 8
Last. Norimasa Iwasaki (Hokkaido University)H-Index: 45
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BACKGROUND Ultrapurified alginate (UPAL) gel implantation has been demonstrated as effective in cartilage repair for osteochondral defects; however, cell transplantation within UPAL gels would be required to treat larger defects. HYPOTHESIS The combination of UPAL gel and bone marrow aspirate concentrate (BMAC) would enhance cartilage repair and subchondral bone repair for large osteochondral defects. STUDY DESIGN Controlled laboratory study. METHODS A total of 104 osteochondral defects (1 defec...
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#1Johtaro Yamamoto (AIST: National Institute of Advanced Industrial Science and Technology)H-Index: 8
#2Akito Matsui (Hokkaido University)
Last. Masataka Kinjo (Hokkaido University)H-Index: 44
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Macromolecular crowding (MMC) in cells is a hot topic in biology; therefore, well-characterized measurement standards for the evaluation of the nano-environment in MMC solutions are necessary. We propose to use polarization-dependent fluorescence correlation spectroscopy (Pol-FCS) for evaluation of macromolecular crowding in solutions. Pol-FCS can simultaneously measure the relaxation times of rotational and translational diffusion of fluorescent molecules at the same position, even in living ce...
2 CitationsSource
#1Yue Youfeng (AIST: National Institute of Advanced Industrial Science and Technology)
#1Yue Youfeng (AIST: National Institute of Advanced Industrial Science and Technology)
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
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#1Kazuyoshi Yamazaki (Hokkaido University)H-Index: 9
#2Toshiya Osanai (Hokkaido University)H-Index: 14
Last. Jian Ping Gong (Hokkaido University)H-Index: 79
view all 13 authors...
The double network (DN) gel is a rigid, tough, and safe hydrogel; however, like all hydrogels and existing particle embolization materials composed of a polymer, they lack X-ray visibility. Thus, it is not possible to locate the embolization material in the body. In this study, we successfully developed an X-ray-visible embolization material, a tough DN gel incorporated with biocompatible heavy metal powder. The DN gel particles, composed of poly(N,N'-dimethylacrylamide) and poly(2-acrylamido-2-...
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#1Sairam Pamulaparthi Venkata (Cornell University)H-Index: 1
#2Kunpeng Cui (Hokkaido University)H-Index: 19
Last. Chung-Yuen Hui (Hokkaido University)H-Index: 70
view all 6 authors...
A finite strain nonlinear viscoelastic constitutive model is used to study the uniaxial tension behaviour of chemical polyampholyte (PA) gel. This PA gel is cross-linked by chemical and physical bonds. Our constitutive model attempts to capture the time and strain dependent breaking and healing kinetics of physical bonds. We compare model prediction by uniaxial tension, cyclic and relaxation tests. Material parameters in our model are obtained by least squares optimization. These parameters gave...
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