Tumor-intrinsic and -extrinsic determinants of response to blinatumomab in adults with B-ALL
Abstract
Blinatumomab, a bispecific antibody that directs CD3+ T cells to CD19+ tumor cells, shows variable efficacy in B-progenitor acute lymphoblastic leukemia (B-ALL). To determine tumor-intrinsic and -extrinsic determinants of response, we studied 44 adults with relapsed or refractory B-ALL (including 2 minimal residual disease positive) treated with blinatumomab using bulk tumor and single-cell sequencing. The overall response rate in patients with...
Paper Details
Title
Tumor-intrinsic and -extrinsic determinants of response to blinatumomab in adults with B-ALL
Published Date
Jan 28, 2021
Journal
Volume
137
Issue
4
Pages
471 - 484
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