In the field of tissue engineering, there are several issues to consider when designing biomaterials for implants, including cellular interaction, good biocompatibility, and biochemical activity. Biomimetic mineralization has gained considerable attention as an emerging approach for the synthesis of biocompatible materials with complex shapes, categorized organization, controlled shape, and size in aqueous environments. Understanding biomineralization strategies could enhance opportunities for novel biomimetic mineralization approaches. In this regard, mussel-inspired biomaterials have recently attracted many researchers due to appealing features, such as strong adhesive properties on moist surfaces, improved cell adhesion, and immobilization of bioactive molecules via catechol chemistry. This molecular designed approach has been a key point in combining new functionalities into accessible biomaterials for biomedical applications. Polydopamine (PDA) has emerged as a promising material for biomaterial functionalization, considering its simple molecular structure, independence of target materials, cell interactions for adhesion, and robust reactivity for resulting functionalization. In this review, we highlight the strategies for using PDA to induce the biomineralization of hydroxyapatite (HA) on the surface of various implant materials with good mechanical strength and corrosion resistance. We also discuss the interactions between the PDA-HA coating, and several cell types that are intricate in many biomedical applications, involving bone defect repair, bone regeneration, cell attachment, and antibacterial activity.
#1Meng Zhang(CCNU: Central China Normal University)H-Index: 6
#2Jiting Zhang(CCNU: Central China Normal University)H-Index: 6
Last. Ying Wan(HUST: Huazhong University of Science and Technology)H-Index: 2
view all 7 authors...
Layered osteochondral composite scaffolds are considered as a promising strategy for the treatment of osteochondral defects. However, the insufficient osseous support and integration of the subchondral bone layer frequently result in the failure of osteochondral repair. Therefore, it is essentially important to explore new subchondral bone constructs tailored to support bone integration and healing. In this study, a novel three-dimensional porous biomimetic construct (HA/pDA-OTMS) was successful...
Successful materials design for bone-tissue engineering requires an understanding of the composition and structure of native bone tissue, as well as appropriate selection of biomimetic natural or tunable synthetic materials (biomaterials), such as polymers, bioceramics, metals and composites. Scalable fabrication technologies that enable control over construct architecture at multiple length scales, including three-dimensional printing and electric-field-assisted techniques, can then be employed...
#2Saeid Kargozar(MUMS: Mashhad University of Medical Sciences)H-Index: 26
Last. Sung Soo Han(Yeungnam University)H-Index: 29
view all 4 authors...
Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bio-apatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable and potentially scalable fabri...
Last. Xiong Lu(Southwest Jiaotong University)H-Index: 46
view all 10 authors...
: Repairing osteochondral defects is a considerable challenge because it involves the breakdown of articular cartilage and underlying bone. Traditional hydrogels with a homogenized single-layer structure cannot fully restore the function of osteochondral cartilage tissue. In this study, a mussel-inspired hydrogel with a bilayer structure is developed to repair osteochondral defects. The hydrogel is synthesized by simultaneously polymerizing two layers using a one-pot method. The resulting upper ...
: A method to mediate biomineralization of electrospinning poly(L-lactide) (PLLA) fibrous membrane assisted by polydopamine (PDA) coating was developed to obtain enhanced osteoconductive activity. The biomineralization mechanism, surface composition, morphology and hydrophilicity of the original and modified PLLA fibrous membranes were characterized. Results revealed that the PDA coating effectively accelerated the formation of hydroxyapatite (HA) on PLLA fibrous membrane and resulted a great in...
Last. Xiong Lu(Southwest Jiaotong University)H-Index: 46
view all 13 authors...
: Conductive polymers are promising for bone regeneration because they can regulate cell behavior through electrical stimulation; moreover, they are antioxidative agents that can be used to protect cells and tissues from damage originating from reactive oxygen species (ROS). However, conductive polymers lack affinity to cells and osteoinductivity, which limits their application in tissue engineering. Herein, an electroactive, cell affinitive, persistent ROS-scavenging, and osteoinductive porous ...
Abstract In this study, mussel-inspired polydopamine nanospheres (∼400 nm) were synthesized via spontaneous oxidative polymerization of dopamine hydrochloride. The creation of bioactive template provided an opportunity for the biomimetic formation of hydroxyapatite layers through soaking of polymeric samples in 10 × -simulated body fluid (10 × -SBF) solution and heating microwave radiation. According to the results, microwave irradiation supported the rapid and homogeneous formation of HA on the...
#1Meng Wu(NUAA: Nanjing University of Aeronautics and Astronautics)H-Index: 3
#2Tao Wang(NUAA: Nanjing University of Aeronautics and Astronautics)H-Index: 1
Last. Hui Wang(NUAA: Nanjing University of Aeronautics and Astronautics)H-Index: 1
view all 4 authors...
Abstract The growing bone-like apatite layer at the tissue-implant interface is the essential condition for materials to bond robustly to surrounding bone and may provide a favorable environment for living bone formation. Inspired by versatility of mussel adhesive proteins, we developed an ultrafast and accessible route to accelerate effectively the formation of amorphous calcium phosphate (ACP), the precursor phase of bone-like apatite, on the surface of polydopamine (PDA)-coated tricalcium sil...
#1Meng Wu(NUAA: Nanjing University of Aeronautics and Astronautics)H-Index: 3
#2Tao Wang(NUAA: Nanjing University of Aeronautics and Astronautics)H-Index: 1
Last. Huang Weixing(NUAA: Nanjing University of Aeronautics and Astronautics)H-Index: 1
view all 4 authors...
Abstract A layer of polydopamine (PDA) was successfully deposited on hydrated tricalcium silicate (TCS) substrate via facile dip-coating of hydrated TCS disk in an aqueous solution of dopamine. The results showed that the continuous release of Ca(OH)2 from hydrated TCS substrate accelerated reaction of noncovalent self-assembly and covalent polymerization of dopamine and therefore a faster deposition of PDA coating on hydrated TCS substrate. Furthermore, amorphous calcium phosphate (ACP) that is...
Last. Feng Wu(Shanxi Medical University)H-Index: 2
view all 0 authors...
Abstract null null Biochemical modification can endow the surface of implants with superior biological activity. Herein, silk fibroin (SF) protein and its anionic derivative peptides (Cs) were covalently immobilized onto a titanium implant surface via a polydopamine layer. The successful conjugation of SF and Cs was revealed by X-ray photoelectron spectroscopy (XPS), field-emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM) and contact angle measurements. The addition o...
Magnesium and its alloys have become potential implant materials in the future because of light weight, mechanical properties similar to natural bone, good biocompatibility, and degradability in physiological environment. However, due to the rapid corrosion and degradation of magnesium alloys in vivo, especially in the environment containing chloride ions, the application of magnesium alloys as implant materials has been limited. Therefore, improving the corrosion resistance of magnesium alloy a...
Abstract Polydopamine (PDA) has shown great potentials in biomedical fields due largely to its unique physicochemical properties, including high photothermal transfer efficiency, excellent drug binding capacity, versatile adhesion ability, sensitive pH responsibility and great biocompatibility and biodegradability. These properties confer PDA-based nanoparticles the potentials either as the drug carriers for advanced drug delivery or as the bioactive agents for photothermal therapy, imaging and ...
BACKGROUND To investigate osteointegration at the graft-bone interface and the prevention of osteoarthritis after anterior cruciate ligament (ACL) reconstruction using a silk-collagen scaffold with both ends modified by hydroxyapatite (HA) in a rabbit model. METHODS The HA/silk-collagen scaffold was fabricated using a degummed, knitted silk scaffold, collagen I matrix, and simulated body fluid (SBF). The HA/silk-collagen scaffold was rolled up to make a graft for replacing the native ACL in the ...
Last. Pradeep Kumar(Institute of Genomics and Integrative Biology)H-Index: 42
view all 4 authors...
The drug resistance developed by bacteria during antibiotic treatment has been a call to action for researchers and scientists across the globe as bacteria and fungi develop ever increasing resistance to current drugs. Innovative antimicrobial/antibacterial materials and coatings to combat such infections has become a priority as many infections are caused by indwelling implants (e.g. catheters) as well as improving post-surgical function and outcomes. Pathogenic microorganisms which can exist e...