The Mechanism of Tubulin Assembly into Microtubules: Insights from Structural Studies
Abstract
Microtubules are cytoskeletal components involved in pivotal eukaryotic functions such as cell division, ciliogenesis, and intracellular trafficking. They assemble from αβ-tubulin heterodimers and disassemble in a process called dynamic instability, which is driven by GTP hydrolysis. Structures of the microtubule and of soluble tubulin have been determined by cryo-EM and by X-ray crystallography, respectively. Altogether, these data define the...
Paper Details
Title
The Mechanism of Tubulin Assembly into Microtubules: Insights from Structural Studies
Published Date
Sep 1, 2020
Journal
Volume
23
Issue
9
Pages
101511 - 101511
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