Abstract 351: Alterations in immune cell signatures during breast cancer metastasis at single cell resolution

Metastasis is the major cause of cancer-related deaths due to insufficient therapeutic effects of conventional treatment. Individual tumor cells exhibit heterogeneous features and growth potentials within the same tumor. This intra-tumor heterogeneity influences the ability of the tumor to form metastasis. The underlying mechanisms of why some tumor cells can give rise to metastases, whereas others cannot are remarkably poorly understood. Tumor...