Cell biology

Nanoparticle

Bacteria

Biology

Biomedical engineering

Metallurgy

Materials science

Biocompatible material

Surgery

Regeneration (biology)

Dentistry

Bone healing

Genetics

Nanotechnology

Lactic acid

Biocompatibility

Medicine

PLGA

Glycolic acid

Bioactive Materials

Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics. Recently, poly(lactic-co-glycolic acid) (PLGA)-based artificial bone-substitute materials are attracting increasing attention as the benefit of their suitable biocompatibility, degradability, mechanical properties, and capabilities to promote bone regeneration. In this article, we comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances, elaborate on their applications for bone regeneration with or without bioactive factors, and prospect the challenges and opportunities in clinical bone regeneration.

Poly(lactic-co-glycolic acid)-based composite bone-substitute materials