Bioactive Materials
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#1Xiaogang Wang (ECUST: East China University of Science and Technology)
#2Yuanman Yu (ECUST: East China University of Science and Technology)H-Index: 11
Last. Changsheng Liu (ECUST: East China University of Science and Technology)H-Index: 65
view all 6 authors...
Abstract Calcium phosphate-based materials (CaP) have been widely used as bone graft substitutes with a decent osseointegration. However, the mechanism whereby cells function and repair the bone defect in CaP micro-environment is still elusive. The aim of this study is to find the mechanism how osteoclast behaviors mediate bone healing with CaP scaffolds. Recent reports show that behaviors of osteoclast are closely related with osteogenesis, thus we make a hypothesis that active osteoclast behav...
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#1Lijing HaoH-Index: 10
#2Tianjie Li (CUHK: The Chinese University of Hong Kong)H-Index: 6
Last. Wang Yingjun (MOE: Chinese Ministry of Education)H-Index: 1
view all 7 authors...
Abstract Fibronectin (Fn) is significant to the performance of biomaterials, and the chemistry of biomaterial surface play important roles in Fn adsorption and subsequent cell behavior. However, the “molecular scale” mechanism is still unclear. Herein, we combined experimental strategies with molecular simulations to solve this problem. We prepared self-assembled monolayers with varying chemistries, i.e., SAMs-CH3, SAMs-NH2, SAMs-COOH and SAMs-OH, and characterized Fn adsorption and cell behavio...
1 CitationsSource
#1Lei Fan (Southern Medical University)H-Index: 7
#2Pengfei Guan (SYSU: Sun Yat-sen University)H-Index: 1
Last. Chengyun Ning (SCUT: South China University of Technology)H-Index: 28
view all 12 authors...
The host immune response effecting on biomaterials is critical to determine implant fates and bone regeneration property. Bone marrow stem cells (BMSCs) derived exosomes (Exos) contain multiple biosignal molecules and have been demonstrated to exhibit immunomodulatory functions. Herein, we develop a BMSC-derived Exos-functionalized implant to accelerate bone integration by immunoregulation. BMSC-derived Exos were reversibly incorporated on tannic acid (TA) modified sulfonated polyetheretherketon...
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#1Xu CuiH-Index: 14
#2Yadong ZhangH-Index: 14
Last. Haobo PanH-Index: 35
view all 16 authors...
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#1Jagoda Litowczenko (Adam Mickiewicz University in Poznań)H-Index: 5
#2Marta J. Woźniak-Budych (Adam Mickiewicz University in Poznań)H-Index: 8
Last. Bartosz TylkowskiH-Index: 16
view all 6 authors...
Abstract Tissue engineering (TE) is a rapidly growing interdisciplinary field, which aims to restore or improve lost tissue function. Despite that TE was introduced more than 20 years ago, innovative and more sophisticated trends and technologies point to new challenges and development. Current challenges involve the demand for multifunctional bioscaffolds which can stimulate tissue regrowth by biochemical curves, biomimetic patterns, active agents and proper cell types. For those purposes espec...
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#1Weiduo Hou (ZJU: Zhejiang University)H-Index: 4
#2Chenyi Ye (ZJU: Zhejiang University)H-Index: 12
Last. Xiaojun Cai (SJTU: Shanghai Jiao Tong University)H-Index: 10
view all 10 authors...
Abstract Osteoarthritis (OA) is the main cause of disability in the elderly. Effective intervention in the early and middle stage of osteoarthritis can greatly prevent or slow down the development of the disease, and reduce the probability of joint replacement. However, there is to date no effective intervention for early and middle-stage OA. OA microenvironment mainly destroys the balance of oxidative stress, extracellular matrix synthesis and degradation of chondrocytes under the joint action ...
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#1Yuanlong Guo (SYSU: Sun Yat-sen University)H-Index: 2
#2Jiaomei Mi (SYSU: Sun Yat-sen University)H-Index: 1
Last. Krasimir Vasilev (UniSA: University of South Australia)H-Index: 54
view all 0 authors...
Abstract null null Micro/nano topographic structures have shown great utility in many biomedical areas including cell therapies, tissue engineering, and implantable devices. Computer-assisted informatics methods hold great promise for the design of topographic structures with targeted properties for a specific medical application. To benefit from these methods, researchers and engineers require a highly reusable “one structural parameter – one set of cell responses” database. However, existing c...
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#1Zhouguang Wang (WMU: Wenzhou Medical College)H-Index: 1
#1Zhouguang Wang (WMU: Wenzhou Medical College)H-Index: 24
Last. Xiaokun Li (WMU: Wenzhou Medical College)H-Index: 73
view all 8 authors...
Abstract Heart disease is still the leading killer all around the world, and its incidence is expected to increase over the next decade. Previous reports have already shown the role of fibroblast growth factor10 (FGF10) in alleviating heart diseases. However, FGF10 has not been used to treat heart diseases because the free protein has short half-life and low bioactivity. Here, an injectable coacervate was designed to protect growth factor from degradation during delivery and the effects of the F...
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#1Muyue Yang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Jipeng Li (SJTU: Shanghai Jiao Tong University)H-Index: 12
Last. Xianqun Fan (SJTU: Shanghai Jiao Tong University)H-Index: 34
view all 4 authors...
Abstract The tumor development and metastasis are closely related to the structure and function of the tumor microenvironment (TME). Recently, TME modulation strategies have attracted much attention in cancer immunotherapy. Despite the preliminary success of immunotherapeutic agents, their therapeutic effects have been restricted by the limited retention time of drugs in TME. Compared with traditional delivery systems, nanoparticles with unique physical properties and elaborate design can effici...
9 CitationsSource
#1Yikai Wang (ZJU: Zhejiang University)H-Index: 1
#2Wangsiyuan Teng (ZJU: Zhejiang University)H-Index: 6
Last. Zhaoming Ye (ZJU: Zhejiang University)H-Index: 19
view all 15 authors...
Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles. However, ordinary antimicrobial treatments usually failed to combat multiple waves of infections during arthroplasty and prosthesis revisions etc. As these incidents could easily introduce new microbial pathogens in/onto the implants. Herein, we demonstrate that an antimicrobial trilogy strategy incorporating a sophisticated multilayered coating system leveraging multiple i...
2 CitationsSource
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