Functional Connectivity Changes in Obsessive–Compulsive Disorder Correspond to Interference Control and Obsessions Severity

Introduction: Deficit in neurocognitive mechanisms such as inhibition control and cognitive flexibility have been suggested to mediate the symptoms in obsessive-compulsive disorder (OCD). These mechanisms are proposedly controlled by the ‘affective’ and ‘executive’ orbitofronto-striato-thalamo-cortical (CSTC) circuits with well documented morphological and functional alterations in OCD that are associated with OCD symptoms. The precuneus region...