Comprehensive Genomic Profiling of Upper-tract and Bladder Urothelial Carcinoma

Characterization of the different genomic alterations (GAs) in urothelial carcinoma (UC), by site of origin, may identify contrasting therapeutic opportunities and inform distinct putative pathogenetic mechanisms.To describe the genomic landscape of UC based on the anatomic site of the primary tumor.In total, 479 upper tract UC (UTUC) and 1984 bladder UC (BUC) patients underwent comprehensive genomic profiling (CGP) to evaluate all classes of...