A nanocomposite based on an antibiotic-loaded hydrogel into a nano-electrospun fibre with antimicrobial and antioxidant capacities is investigated. The material is composed of nanofibres of enzymatic PCL grafted with poly(gallic acid) (PGAL), a recently developed enzyme-mediated hydrophilic polymer that features a multiradical and polyanionic nature in a helicoidal secondary structure. An extensive experimental–theoretical study on the molecular structure and morphological characterizations for this nanocomposite are discussed. The hydrogel network is formed by sodium carboxymethylcellulose (CMC) loaded with the broad-spectrum antibiotic clindamycin. This nano electrospun biomaterial inhibits a strain of Staphylococcus aureus, which is the main cause of nosocomial infections. The SPTT assay demonstrates that PGAL side chains also improve the release rates for this bactericide owing to the crosslinking to the CMC hydrogel matrix. The absence of hemolytic activity and the viability of epithelial cells demonstrates that this nanocomposite has no cytotoxicity.
Last. Miquel Gimeno(UNAM: National Autonomous University of Mexico)H-Index: 18
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Abstract Enzymatic mediated poly (gallic acid) (PGAL), a stable multiradical polyanion with helicoidal secondary structure and high antioxidant capacity, was successfully grafted to poly(e-caprolactone) (PCL) using UV-photo induction. PCL films were prepared with several levels of roughness and subsequently grafted with PGAL (PCL-g-PGAL). The results on the full characterization of the produced materials by mechanical tests, surface morphology, and topography, thermal and crystallographic analys...
#1Hien A. Tran(QUT: Queensland University of Technology)H-Index: 4
#2Khanh L. Ly(VNUHCM: Vietnam National University, Ho Chi Minh City)H-Index: 3
Last. Thi-Hiep Nguyen(VNUHCM: Vietnam National University, Ho Chi Minh City)H-Index: 17
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Purpose The aim of this study is to develop a new coating for wound dressings that is comprised of antimicrobial silver (Ag) and antioxidant flavonoid quercetin (Q).
#2Miquel Gimeno(UNAM: National Autonomous University of Mexico)H-Index: 18
Last. Pablo Labra-Vázquez(UNAM: National Autonomous University of Mexico)H-Index: 5
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Abstract In this work we re-examined the molecular structure of enzymatic poly(gallic acid) (PGAL), for which we identified a multiradical and polyanionic nature, in contrast to a previous assignment where it was mistakenly assumed as a neutral and diamagnetic molecule. Here, we present a profound investigation of its ground-state structure by the use of both experimental and theoretical methods, featuring ESR measurements and quantum chemical computations. It was found that its multiradical nat...
Last. Orazio Vittorio(UNSW: University of New South Wales)H-Index: 25
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A multi-functional composite to be employed as a dressing material was prepared by combining hydrogel and microparticle systems. For the synthesis of the hydrogel counterpart, a free radical polymerization was carried out using a gelatin–curcumin conjugate, previously obtained through immobilized laccase catalysis, and polyethylene glycol dimethacrylate as a functional element, plasticizer, and crosslinker. The hydrogel was found to possess high water affinity, biocompatibility, and the ability ...
Last. Inho Hwang(CBNU: Chonbuk National University)H-Index: 19
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Our investigation for the first time explores the possibility of fabrication of a Capsaicin/polyurethane-based bioactive wound dressing. A micro/nanofibrous bandage was synthesized by electrospinning polyurethane supplemented with natural anti-inflammatory agent, Capsaicin. Herein, the best concentration (3%) of Capsaicin in polyurethane to get a consistent solution was standardized in order to acquire the composite micro/nanofibrous dressing. The as-spun bandage has been investigated by scannin...
#1Mattia Comotto(MIT: Massachusetts Institute of Technology)H-Index: 5
#2Saghi Saghazadeh(MIT: Massachusetts Institute of Technology)H-Index: 6
Last. Ali Tamayol(MIT: Massachusetts Institute of Technology)H-Index: 49
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Traditional wound dressings are not effective enough to regulate the moisture content and remove excessive exudate from the environment. Wet wound dressings formed from hydrogels such as alginate a...
#2Petya Petkova(UPC: Polytechnic University of Catalonia)H-Index: 9
Last. Tzanko Tzanov(UPC: Polytechnic University of Catalonia)H-Index: 37
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BACKGROUND: Composed in a large extent of water and due to their nonadhesiveness, hydrogels found their way to the wound dressing market as materials that provide a moisture environment for healing while being comfortable to the patient. Hydrogels' exploitation is constantly increasing after evidences of their even broader therapeutic potential due to resemblance to dermal tissue and ability to induce partial skin regeneration. The innovation in advanced wound care is further directed to the dev...
#1Ingo Ludolph(FAU: University of Erlangen-Nuremberg)H-Index: 13
#2Frederik W. Fried(FAU: University of Erlangen-Nuremberg)H-Index: 2
Last. Raymund E. Horch(FAU: University of Erlangen-Nuremberg)H-Index: 59
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: Microbial wound contamination is known to be a hindrance to wound healing. Negative pressure wound therapy (NPWT) with or without irrigation is known to optimise conditions in problem wounds. The aim of this study was to investigate the influence of computer-controlled wound irrigation with NPWT on the bacterial load in contaminated wounds. A total of 267 patients were treated with NPWT with automated instillation because of problematic wounds using an antiseptic instillation solution. In 111 ...
#1Suhela Tyeb(IITK: Indian Institute of Technology Kanpur)H-Index: 3
#2Nitesh Kumar(IITK: Indian Institute of Technology Kanpur)H-Index: 6
Last. Vivek Verma(IITK: Indian Institute of Technology Kanpur)H-Index: 15
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Abstract Chronic wounds suffer impaired healing that results in psychological effect and morbity in addition to economic burden on the patient. These wounds are characterized by prolonged inflammatory phase, poor collagen production, hampered angiogenesis, upregulation in reactive oxygen species (ROS) and matrix metalloproteases (MMP). In the current work, three different concentrations (03:01, 05:01 and 10:01) of flexible agar-sericin-glycerol hydrogel films with sericin as minor component were...
#1Sween Gilotra(IITG: Indian Institute of Technology Guwahati)H-Index: 3
#2Dimple Chouhan(IITG: Indian Institute of Technology Guwahati)H-Index: 12
Last. Biman B. Mandal(IITG: Indian Institute of Technology Guwahati)H-Index: 38
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Abstract Wound dressing developed using bioactive materials has been a current area of research for treating chronic non-healing wounds owing to its high demand. Here, we report the fabrication and evaluation of nanofibrous matrix based wound dressings using biopolymer poly(vinyl alcohol) (PVA) incorporated with silk sericin (SS). SS extracted from the cocoons of mulberry variety Bombyx mori and non-mulberry variety Antheraea assama has been used to develop two types of blended mats. Herein, SS ...
#1Brinta Bhattacharjee(Jawaharlal Nehru Centre for Advanced Scientific Research)H-Index: 2
#2Sreyan Ghosh(Jawaharlal Nehru Centre for Advanced Scientific Research)H-Index: 4
Last. Jayanta Haldar(Jawaharlal Nehru Centre for Advanced Scientific Research)H-Index: 33
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Escalating medical expenses due to infectious diseases are causing huge socioeconomic pressure on mankind globally. The emergence of antibiotic resistance has further aggravated this problem. Drug-resistant pathogens are also capable of forming thick biofilms on biotic and abiotic surfaces to thrive in a harsh environment. To address these clinical problems, various strategies including antibacterial agent delivering matrices and bactericidal coatings strategies have been developed. In this revi...
Last. Pooyan Makvandi(IIT: Istituto Italiano di Tecnologia)H-Index: 20
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In this study, nanocomposite hydrogels composed of sodium carboxymethylated starch (CMS)-containing CuO nanoparticles (CMS@CuO) were synthesized and used as experimental wound healing materials. The hydrogels were fabricated by a solution-casting technique using citric acid as a crosslinking agent. They were characterized by Fourier-transform infrared spectroscopy (FTIR), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and...
Last. Miquel Gimeno(UNAM: National Autonomous University of Mexico)H-Index: 18
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Abstract Microwave-mediated grafting of L-Arg onto naturally derived and stable multiradical poly(gallic acid) (PGAL) in aqueous media has been successfully achieved. This polymeric material has no adverse effect in human cells as there is no hemolytic activity upon MTT and Neutral Red assays. The analytical and computational characterization studies carried out in this study describe a helical molecular structure with random incorporation of L-Arginine pendant groups from PGAL's backbone. The a...